대한지역사회작업치료학회지 (The Journal of Korean society of community based occupational therapy)

대한지역사회작업치료학회 (Korean Society of Community Based Occupational Therapy Association)
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환경적용이 수면장애 모델 쥐의 혈중 멜라토닌 농도에 미치는 영향

Effect of Different Environmental Application on Blood Melatonin Density in Sleep Disordered Rats

  • 장상훈 (김천대학교 물리치료학과) ;
  • 김동현 (김천대학교 작업치료학과)
  • 투고 : 2017.03.20
  • 심사 : 2017.04.18
  • 발행 : 2017.04.30
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초록

목적 : 본 연구는 수면장애 동물모델 쥐에게 환경변화를 적용하였을 때, 혈 중 멜라토닌의 변화를 통하여 수면장애 개선 효과를 확인하는데 그 목적이 있다. 연구방법 : 본 연구는 경북 소재의 동물실험실에서 실험을 진행하였고 수면장애 모델의 흰쥐 26마리에게 적용하였다. 3일간 환경변화를 적용한 실험군과 일반 케이지에서 환경변화를 적용받지 못한 대조군의 수면장애 모델 쥐 각각 13마리의 혈 중 멜라토닌의 농도를 확인하였다. 결과 : 수면장애 모델 쥐에게 환경변화를 적용한 결과, 환경 적용 후 실험군에서는 3일간 일별 멜라토닌 농도의 변화는 유의하게 증가하였고(p=.000), 대조군은 3일간 일별 멜라토닌 농도의 변화는 약간의 증가는 있었지만 유의한 변화는 없었다(p=.212). 환경 적용 전, 후 멜라토닌 농도의 변화는 실험군, 대조군 모두 유의한 차이를 보였지만 실험군에서는 멜라토닌 농도의 유의미한 증가가 있었고, 대조군에서는 멜라토닌 농도의 유의미한 감소가 있었다. 결론 : 수면장애 환자가 증가하고 있는 현대사회에서 환자들에게 적용되어지는 환경적용이 수면장애에 어떠한 영향을 주는지 확인하기 위해 동물모델을 제작하였고 인간의 환경변화와 유사한 환경변화를 적용하였으며 이를 통해 수면장애의 개선효과를 확인할 수 있었다.

Objective : The study was to find out the effect of sleep disorder bt melatonin when we applied the evironmental change to rats wirh sleep disorder. Methods : We performed the study in lab which is located in Gyungbuk. We divided 26 rats into two groups. The experimental group had the environmental change for 3 days. The control group didn't have the change. We checked the level of melatonin of each group. Results : There was a significant difference of the level of melatonin in experimental group after applying the environmental change for 3 days (p=.000). The level of melatonin was increased a little for 3 each day in control group, but there was no significance(p=.212). There was a significant difference of the level of melatonin in both groups before and after applying the environmental change. However, the level of melatonin was increased significantly in experimental group, and the level was decreased significantly in control group. Conclusion : The patients with sleep disorder are increasing in modern society. We made a animal model with sleep disorder to find out the effect of the environmental change. We applied the environment like human's and could know the improvement effect of sleep disorder.

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참고문헌

  1. Americal Occupational Therapy Association. (2009). Occupational Therapy practice framework: domain and process 2nd edition. American Journal of Occupational Therapy, 62(2), 625-683.
  2. Brabbins C. J., Dewey, M. E., Copeland, J. R. M., Davidson, I. A. (1993). Insomnia in the elderly: prevalence, gender differences and relationships with morbidity and mortality. International Journal of Geriatric Psychiatry, 8(6), 473-480. https://doi.org/10.1002/gps.930080604
  3. Chennaoui M., Arnal P. J., Sauvet F., Leger D. (2015). Sleep and exercise: A reciprocal issue? Sleep Medicine Review, 10, 59-72.
  4. Foley, D. J., Monjan, A. A., Brown, S. L., Simonsick, E. M. (1995). Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep, 18(6), 425-432. https://doi.org/10.1093/sleep/18.6.425
  5. Hagewoud, R., Havekes, R., Novati, A., Keijser, J. N., VAN, D. Z., Meerlo, P. (2010). Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation. Journal of Sleep Research, 19(2), 280-288. https://doi.org/10.1111/j.1365-2869.2009.00799.x
  6. Jang, I. S., Choi, M. H. (2008). The Effect of the Environmental Nursing Intervention on ICU Delirium, Environmental Stress and Sleep in Patients Underwent Cardiac Surgical Procedures. Journal of Korean Clinical Nursing Research, 14(2), 127-138.
  7. Kang, K, A., Seong, H, H., Jin, H. B., Park, J, M., Lee, J, M., Jeon, J, Y., et al. (2011). The Effect of Treadmill Exercise on Ischemic Neuronal Injury in the Stroke Animal Model: Potentiation of Cerebral Vascular Integrity. Journal of Korean Academy of Nursing, 41(2), 197-203. https://doi.org/10.4040/jkan.2011.41.2.197
  8. Kasapis, C., & Thompson, P. D. (2005). The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. Journal of the American College of Cardiology, 45(10), 1563-1569. https://doi.org/10.1016/j.jacc.2004.12.077
  9. Kim, D. H. & Bang, H. S. (2016). The Effect of Complex Exercise Program of Diebetic Rats with Ischemic Brain Injury Model. The Journal of Korean Society of Community Based Occupational Therapy, 6(1), 41-48. https://doi.org/10.18598/kcbot.2016.06.01.05
  10. Kim, M. H., Kim, M. J. & Chun, C. Y. (2008). The Research on Sleep Environment and Sleep Quality in Winter and Spring. Korean Institute of Architactural Sustaiable Environment and Building Systems, 125-128.
  11. Kwon, Y. S. (2001). The effect of environmental adaptive training on motor function and expression of BDNF and pCREB after middle cerebral artery occlusion in the rats. doctoral dissertation, University of deagu, gyeongsan.
  12. Lange, T., Dimitrov, S., Born, J. (2010). Effects of sleep and circadian rhythm on the human immune system. Annals of the New York Academy of Sciences, 1193, 48-59. https://doi.org/10.1111/j.1749-6632.2009.05300.x
  13. Luyster, F., Strollo, P., Zee, P., Walsh, J. (2012). Sleep: a health imperative. Sleep 35(6), 727. https://doi.org/10.5665/sleep.1846
  14. National Sleep Foundation. (2009). Sleep in America poll, Washington, DC, 2009, National Sleep Foundation.
  15. Passos, G. S., Poyares, D., Santana, M. G., D'Aurea, C. V., Youngstedt, S. D., Tufik, S., et al. (2011). Effects of moderate aerobic exercise training on chronic primary insomnia. Sleep Medicine, 12(10), 1018-1027. https://doi.org/10.1016/j.sleep.2011.02.007
  16. Passos, G. S., Poyares, D., Santana, M. G., Garbuio, S. A., Tufik, S., Mello, M. T. (2010). Effect of acute physical exercise on patients with chronic primary insomnia. Journal of Clinical Sleep Medicine, 6(3), 270-275.
  17. Pober, D. M., Braun, B., Freedson, P. S. (2004). Effects of a single bout of exercise on resting heart rate variability. Medicine and Science in Sports and Exercise, 36, 1140-1148. https://doi.org/10.1249/01.MSS.0000132273.30827.9A
  18. Reis, E. S., Lange, T., Kohl, G., Herrmann, A., Tschulakow, A. V., Naujoks, J. (2011). Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a. Brain, Behavior, and Immunity, 25(7), 1416-1426.
  19. Ryu, H. J., Moon, J. M. (2012). A Study on Residential Environment using the Concept of Therapeutic Design - Centering on Bedroom Environment. Journal of Korea Design Knowledge, 21, 11-20.
  20. Scheen, A. J., Byrne, M. M., Plat, L., Leproult, R., Van Cauter. E. (1996). Relationships between sleep quality and glucose regulation in normal humans. American Journal of Physiology, 271(2) 261-270. https://doi.org/10.1152/ajpendo.1996.271.2.E261
  21. Seiler, S., Haugen, O., Kuffel, E. (2007). Autonomic recovery after exercise in trained athletes: intensity and duration effects. Medicine and Science in Sports and Exercise, 39, 1366-1373. https://doi.org/10.1249/mss.0b013e318060f17d
  22. Somers, V. K., Dyken, M. E., Mark, A. L., Abboud, F. M. (1993). Sympathetic-nerve activity during sleep in normal subjects. The New England Journal of Medicine, 328, 303-307. https://doi.org/10.1056/NEJM199302043280502
  23. Stein, P. K., Pu, Y. (2007). Heart rate variability, sleep and sleep disorders. Sleep Medicine Review, 1647-1666.
  24. Turek, F. W., Gillette, M. U. (2004). Melatonin, sleep, and circadian rhythms: rational for development of specific melatonin agonists. Sleep Medicine, 5, 523-532. https://doi.org/10.1016/j.sleep.2004.07.009
  25. Uchida, S., Shioda, K., Morita, Y., Kubota, C., Ganeko, M., Takeda, N. (2012). Exercise effects on sleep physiology. Frontiers in Neurology, 3, 48.
  26. Vaynman, S., Ying, Z., Gomez Pinilla, F. (2004). Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. European Journal of Neuroscience, 20(10), 2580-2590. https://doi.org/10.1111/j.1460-9568.2004.03720.x
  27. Yang, P. Y., Ho, K. H., Chen, H. C., Chien, M. Y. (2012). Exercise training improves sleep quality in middle-aged and older adults with sleep problems: a systematic review. Journal of Physiotherapy, 58(3), 157-163. https://doi.org/10.1016/S1836-9553(12)70106-6
  28. Zagaar, M., Alhaider, I., Dao, A., Levine, A., Alkarawi, A., Alzubaidy, M. (2012). The beneficial effects of regular exercise on cognition in REM sleep deprivation: behavioral, electrophysiological and molecular evidence. Neurobiology of Disease, 45(3), 1153-1162. https://doi.org/10.1016/j.nbd.2011.12.039