Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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CTCF, Cohesin, and Chromatin in Human Cancer

  • Song, Sang-Hyun (Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University) ;
  • Kim, Tae-You (Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University)
  • Received : 2017.11.15
  • Accepted : 2017.11.29
  • Published : 2017.12.31
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Abstract

It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.

Keywords

References

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