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http://dx.doi.org/10.5808/GI.2017.15.4.114

CTCF, Cohesin, and Chromatin in Human Cancer  

Song, Sang-Hyun (Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University)
Kim, Tae-You (Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University)
Publication Information
Genomics & Informatics / v.15, no.4, 2017 , pp. 114-122 More about this Journal
Abstract
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.
Keywords
cohesins; CTCF; gene expression regulation; higher-order chromatin structure; topologically associated domain;
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