Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients

  • Yuvaraj, B. (Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)) ;
  • Sridhar, M.G. (Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)) ;
  • Kumar, S. Vinod (Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)) ;
  • Kadhiravan, T. (Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
  • Received : 2015.11.18
  • Accepted : 2016.05.04
  • Published : 2016.07.01
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Abstract

Background: Vitamin D is known to have diverse effects on various systems in the body. There is evidence to suggest that a link exists between the serum vitamin D status and tuberculosis. The present study was designed to assess the alterations in serum 25-hydroxyvitamin D levels in newly diagnosed sputum acid fast bacilli (AFB) positive pulmonary tuberculosis patients and to study the association, if any, between serum vitamin D levels and different levels of sputum smear positivity. Methods: Serum 25-hydroxyvitamin D levels were estimated in 65 sputum AFB positive pulmonary tuberculosis patients and 65 age and gender-matched healthy controls. Results: The levels of serum 25 hydroxy-vitamin D in tuberculosis patients were not statistically different from the levels of serum 25 hydroxy-vitamin D in healthy controls. However, among patients with pulmonary tuberculosis, there was a significant negative correlation between the levels of serum 25 hydroxy-vitamin D and levels of sputum positivity. Conclusion: Serum vitamin D levels negatively correlates with bacterial load in patients with active pulmonary tuberculosis.

Keywords

References

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