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http://dx.doi.org/10.4046/trd.2016.79.3.153

Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients  

Yuvaraj, B. (Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
Sridhar, M.G. (Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
Kumar, S. Vinod (Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
Kadhiravan, T. (Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
Publication Information
Tuberculosis and Respiratory Diseases / v.79, no.3, 2016 , pp. 153-157 More about this Journal
Abstract
Background: Vitamin D is known to have diverse effects on various systems in the body. There is evidence to suggest that a link exists between the serum vitamin D status and tuberculosis. The present study was designed to assess the alterations in serum 25-hydroxyvitamin D levels in newly diagnosed sputum acid fast bacilli (AFB) positive pulmonary tuberculosis patients and to study the association, if any, between serum vitamin D levels and different levels of sputum smear positivity. Methods: Serum 25-hydroxyvitamin D levels were estimated in 65 sputum AFB positive pulmonary tuberculosis patients and 65 age and gender-matched healthy controls. Results: The levels of serum 25 hydroxy-vitamin D in tuberculosis patients were not statistically different from the levels of serum 25 hydroxy-vitamin D in healthy controls. However, among patients with pulmonary tuberculosis, there was a significant negative correlation between the levels of serum 25 hydroxy-vitamin D and levels of sputum positivity. Conclusion: Serum vitamin D levels negatively correlates with bacterial load in patients with active pulmonary tuberculosis.
Keywords
Vitamin D; Tuberculosis; Pulmonary;
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