Journal of Acupuncture Research

  • 제33권2호
  • /
  • Pages.135-150
  • /
  • 2016
  • /
  • 2586-288X(pISSN)
  • /
  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
권호 표지
DOI QR코드

DOI QR Code

비만치료를 목적으로 마테(Yerba Mate, Ilex paraguariensis)를 함유한 복합투여물의 효과 및 부작용에 대한 고찰

A Review of Combination Effects and Adverse Effects of Yerba Mate (Ilex paraguariensis) on the Treatment of Obesity

  • 안재현 (경희대학교 대학원 침구의학교실) ;
  • 이민호 (경희대학교 대학원 침구의학교실) ;
  • 이승훈 (경희대학교 대학원 침구의학교실) ;
  • 최도영 (경희대학교 대학원 침구의학교실) ;
  • 이재동 (경희대학교 대학원 침구의학교실)
  • Ahn, Jae Hyun (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Min Ho (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Seung Hoon (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University) ;
  • Choi, Do Young (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Jae Dong (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2016.05.10
  • 심사 : 2016.05.25
  • 발행 : 2016.06.20
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : The aim of this study is to review the combination effects and adverse effects of Yerba Mate (Ilex paraguariensis) on the treatment of obesity. Methods : Four databases were searched, including Pubmed, National assembly library, RISS4u, and NDSL, for studies published before March 31, 2016 using the keywords 'yerba mate', 'Ilex paraguariensis', and those related to 'obesity'. Clinical trials, and both in vivo and in vitro studies were classified according to the following categories: publication year, nationality, types and composition of test compounds, combination effects, adverse effects, and safety. Results : A total of 16 articles (14 clinical trials, one in vivo, one in vitro) were included in the analysis. Combination effects were reported from six YGD (Yerba Mate, Guarana, Damiana, Zotrim), five Meltdown, one Shred-matrix, one DBX (DymaBurn Xtreme), one XSIII research study, and adverse effects were reported from two YGD (Zotrim), four Meltdown, one Shred-matrix and one MetEF research study. YGD and Shred-matrix increased satiety while YGD and MetEF had adverse gastrointestinal effects potentially due to guarana. Meltdown and Shred-matrix increased energy expenditure and fat oxidation and had the adverse effects of increased heart rate and blood pressure due to the thermogenic effect of caffeine and yohimbine. DBX increased resting energy expenditure but no difference was observed in respiratory exchange ratio. XSIII reduced body weight gain and food intake more than each of the extracts did on their own. Conclusion : Taken together, the combination effects and adverse effects differed according to the composition of test compounds and the ratio of ingredients. Multicomponent approaches should be used for treating multifactorial diseases such as obesity. As a general conclusion, there is a place for a combination of herbal components including yerba mate, based on the principle of Kun-Shin-Choa-Sa for the treatment of obesity.

키워드

참고문헌

  1. Ayyad C, Andersen T. Long-term efficacy of dietary treatment of obesity : a systematic review of studies published between 1931 and 1999. Obes Rev. 2000 ; 1(2) : 113-9. https://doi.org/10.1046/j.1467-789x.2000.00019.x
  2. Gamboa-Gomez CI, Rocha-Guzman NE, Gallegos-Infante JA, Moreno-Jimenez MR, Vazquez-Cabral BD, Gonzalez-Laredo RF. Plants with potential use on obesity and its complications. EXCLI J. 2015 ; 14 : 809-31.
  3. Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M. A systematic review of anti-obesity medicinal plants-an update. J Diabetes Metab Disord. 2013 ; 12(1) : 28. https://doi.org/10.1186/2251-6581-12-28
  4. Gambero A, Ribeiro ML. The positive effects of yerba mate (Ilex paraguariensis) in obesity. Nutrients. 2015 ; 7(2) : 730-50. https://doi.org/10.3390/nu7020730
  5. Mosimann AL, Wilhelm-Filho D, da Silva EL. Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits. BioFactors (Oxford, England). 2006 ; 26(1) : 59-70. https://doi.org/10.1002/biof.5520260106
  6. Arcari DP, Bartchewsky W, dos Santos TW et al. Antiobesity effects of yerba mate extract (Ilex paraguariensis) in high-fat diet-induced obese mice. Obesity (Silver Spring, Md). 2009 ; 17(12) : 2127-33. https://doi.org/10.1038/oby.2009.158
  7. Alkhatib A. Yerba Mate′(Illex Paraguariensis) ingestion augments fat oxidation and energy expenditure during exercise at various submaximal intensities. Nutr Metab(Lond). 2014 ; 11 : 42. https://doi.org/10.1186/1743-7075-11-42
  8. Kang YR, Lee HY, Kim JH et al. Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a highfat diet. Lab Anim Res. 2012 ; 28(1) : 23-9. https://doi.org/10.5625/lar.2012.28.1.23
  9. Hussein GM, Matsuda H, Nakamura S et al. Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice : involvement of glucagon-like peptide-1. Biol Pharm Bull. 2011 ; 34(12) : 1849-55. https://doi.org/10.1248/bpb.34.1849
  10. Arcari DP, Santos JC, Gambero A, Ribeiro ML. The in vitro and in vivo effects of yerba mate (Ilex paraguariensis) extract on adipogenesis. Food Chem. 2013 ; 141(2) : 809-15. https://doi.org/10.1016/j.foodchem.2013.04.062
  11. Andersen T, Fogh J. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutri Diet. 2001 ; 14(3) : 243-50. https://doi.org/10.1046/j.1365-277X.2001.00290.x
  12. Loria D, Barrios E, Zanetti R. Cancer and yerba mate consumption : a review of possible associations. Rev Panam Salud Publica. 2009 ; 25(6) : 530-9. https://doi.org/10.1590/S1020-49892009000600010
  13. Gonzalez de Mejia E, Song YS, Ramirez-Mares MV, Kobayashi H. Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation. J Agric Food Chem. 2005 ; 53(6) : 1966-73. https://doi.org/10.1021/jf048158g
  14. Ramirez-Mares MV, Chandra S, de Mejia EG. In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols. Mutat Res. 2004 ; 554(1-2) : 53-65. https://doi.org/10.1016/j.mrfmmm.2004.03.002
  15. Kiyohara H, Matsumoto T, Yamada H. Combination Effects of Herbs in a Multi-herbal Formula : Expression of Juzen-taiho-to's Immuno-modulatory Activity on the Intestinal Immune System. Evid Based Complement Alternat Med : eCAM. 2004 ; 1(1) : 83-91. https://doi.org/10.1093/ecam/neh004
  16. Hosoya E. Scientific reevaluation of Kampo prescriptions using modern technology. Resent Advances in the Pharmacology of Kampo (Japanese herbal) Medicines. Tokyo, Japan : Excerpta Medica. 1988 : 17-29.
  17. Kim HU, Ryu JY, Lee JO, Lee SY. A systems approach to traditional oriental medicine. Nat Biotechnol. 2015 ; 33(3) : 264-8. https://doi.org/10.1038/nbt.3167
  18. Greenway FL, Whitehouse M, Guttadauria M et al. Rational design of a combination medication for the treatment of obesity. Obesity. 2009 ; 17(1) : 30-9. https://doi.org/10.1038/oby.2008.461
  19. Astrup A, Toubro S, Cannon S, Hein P, Madsen J. Thermogenic synergism between ephedrine and caffeine in healthy volunteers : a doubleblind, placebo-controlled study. Metabolism : clinical and experimental. 1991 ; 40(3) : 323-9. https://doi.org/10.1016/0026-0495(91)90117-F
  20. Kang JG, Park CY. Anti-Obesity Drugs : A Review about Their Effects and Safety. Diabetes Metab J. 2012 ; 36(1) : 13-25. https://doi.org/10.4093/dmj.2012.36.1.13
  21. Waters E, de Silva-Sanigorski A, Hall BJ et al. Interventions for preventing obesity in children. Cochrane Database Syst Rev. 2011 ; 12 : CD001871.
  22. Santos JC, Gotardo EM, Brianti MT, Piraee M, Gambero A, Ribeiro ML. Effects of yerba mate, a plant extract formulation "( YGD") and resveratrol in 3T3-L1 adipogenesis. Molecules (Basel, Switzerland). 2014 ; 19(10) : 16909-24. https://doi.org/10.3390/molecules191016909
  23. Krotkiewski M, Janiak R. Comparison of the weight decreasing effects of different herbs with a mixture of herbal extracts exerting a probable synergistic effect. Praca Oryginalna. 2008 ; 4(4) : 137-42.
  24. Ruxton C. Efficacy of Zotrim : a herbal weight loss preparation. Nutrition & Food Science. 2004 ; 34(1) : 25-8. https://doi.org/10.1108/00346650410516199
  25. Ruxton CHS, Hinton F, Evans CEL. Effects of an over-the-counter herbal weight management product ($Zotrim^{(R)}$) on weight and waist circumference in a sample of overweight women : a consumer study. Nutrition & Food Science. 2005 ; 35(5) : 303-14. https://doi.org/10.1108/00346650510625494
  26. Ruxton C, Kirkwood L, McMillan B, St John D, Evans C. Effectiveness of a herbal supplement ($Zotrim^{(TM)}$) for weight management. British Food Journal. 2007 ; 109(6) : 416-28. https://doi.org/10.1108/00070700710753481
  27. Harrold JA, Hughes GM, O'Shiel K et al. Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice. Appetite. 2013 ; 62 : 84-90. https://doi.org/10.1016/j.appet.2012.11.018
  28. Jitomir J, Nassar E, Culbertson J et al. The acute effects of the thermogenic supplement Meltdown on energy expenditure, fat oxidation, and hemodynamic responses in young, healthy males. J Int Soc Sports Nutr. 2008 ; 5 : 23. https://doi.org/10.1186/1550-2783-5-23
  29. Hoffman JR, Kang J, Ratamess NA, Rashti SL, Tranchina CP, Faigenbaum AD. Thermogenic effect of an acute ingestion of a weight loss supplement. J Int Soc Sports Nutr. 2009 ; 6 : 1. https://doi.org/10.1186/1550-2783-6-1
  30. Bloomer RJ, Fisher-Wellman KH, Hammond KG, Schilling BK, Weber AA, Cole BJ. Dietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained men. J Int Soc Sports Nutr. 2009 ; 6 : 10. https://doi.org/10.1186/1550-2783-6-10
  31. Bloomer RJ, Canale RE, Blankenship MM, Hammond KG, Fisher-Wellman KH, Schilling BK. Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women : a randomized, placebo controlled, cross-over study. Lipids Health Dis. 2009 ; 8 : 32. https://doi.org/10.1186/1476-511X-8-32
  32. Rashti SL, Ratamess NA, Kang J, Faigenbaum AD, Chilakos A, Hoffman JR. Thermogenic effect of meltdown RTD energy drink in young healthy women : a double blind, cross-over design study. Lipids Health Dis. 2009 ; 8 : 57. https://doi.org/10.1186/1476-511X-8-57
  33. Alkhatib A, Seijo M, Larumbe E, Naclerio F. Acute effectiveness of a“ fat-loss” product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise. J Int Soc Sports Nutr. 2015 ; 12 : 44. https://doi.org/10.1186/s12970-015-0105-8
  34. Outlaw J, Wilborn C, Smith A et al. Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures. J Int Soc Sports Nutr. 2013 ; 10(1) : 25. https://doi.org/10.1186/1550-2783-10-25
  35. Vukovich MD, Schoorman R, Heilman C, Jacob P 3rd, Benowitz NL. Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure. Clin Exp Pharmacol Physiol. 2005 ; 32(1-2) : 47-53. https://doi.org/10.1111/j.1440-1681.2005.04152.x
  36. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr. 2006 ; 3 : 35-41. https://doi.org/10.1186/1550-2783-3-1-35
  37. Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. AM J Med. 2005 ; 118(9) : 998-1003. https://doi.org/10.1016/j.amjmed.2005.02.034
  38. Vogel RM, Joy JM, Falcone PH, Mosman MM, Kim MP, Moon JR. Consuming a multi-ingredient thermogenic supplement for 28 days is apparently safe in healthy adults. Food Nutr Res. 2015 ; 59 : 27999. https://doi.org/10.3402/fnr.v59.27999
  39. Min B, McBride BF, Kardas MJ et al. Electrocardiographic effects of an Ephedra-Free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy. 2005 ; 25(5) : 654-9. https://doi.org/10.1592/phco.25.5.654.63581
  40. Rashti SL, Ratamess NA, Kang J, Faigenbaum AD, Chilakos A, Hoffman JR. Thermogenic effect of meltdown $RTD^{TM}$ energy drink in young healthy women : a double blind, cross-over design study. Lipids Health Dis. 2009 ; 8 : 57. https://doi.org/10.1186/1476-511X-8-57
  41. Buchanan SR. The Acute Effects of Shred Matrix on Hemodynamic Responses, Substrate Utilization, Endurance, Arterial Compliance, and Body Water Distribution [dissertation]. Brownsville : University of Texas. 2015. English.