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http://dx.doi.org/10.13045/acupunct.2016023

A Review of Combination Effects and Adverse Effects of Yerba Mate (Ilex paraguariensis) on the Treatment of Obesity  

Ahn, Jae Hyun (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University)
Lee, Min Ho (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University)
Lee, Seung Hoon (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University)
Choi, Do Young (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University)
Lee, Jae Dong (Department of Acupuncture and Moxibustion Medicine, Graduate School, Kyung Hee University)
Publication Information
Journal of Acupuncture Research / v.33, no.2, 2016 , pp. 135-150 More about this Journal
Abstract
Objectives : The aim of this study is to review the combination effects and adverse effects of Yerba Mate (Ilex paraguariensis) on the treatment of obesity. Methods : Four databases were searched, including Pubmed, National assembly library, RISS4u, and NDSL, for studies published before March 31, 2016 using the keywords 'yerba mate', 'Ilex paraguariensis', and those related to 'obesity'. Clinical trials, and both in vivo and in vitro studies were classified according to the following categories: publication year, nationality, types and composition of test compounds, combination effects, adverse effects, and safety. Results : A total of 16 articles (14 clinical trials, one in vivo, one in vitro) were included in the analysis. Combination effects were reported from six YGD (Yerba Mate, Guarana, Damiana, Zotrim), five Meltdown, one Shred-matrix, one DBX (DymaBurn Xtreme), one XSIII research study, and adverse effects were reported from two YGD (Zotrim), four Meltdown, one Shred-matrix and one MetEF research study. YGD and Shred-matrix increased satiety while YGD and MetEF had adverse gastrointestinal effects potentially due to guarana. Meltdown and Shred-matrix increased energy expenditure and fat oxidation and had the adverse effects of increased heart rate and blood pressure due to the thermogenic effect of caffeine and yohimbine. DBX increased resting energy expenditure but no difference was observed in respiratory exchange ratio. XSIII reduced body weight gain and food intake more than each of the extracts did on their own. Conclusion : Taken together, the combination effects and adverse effects differed according to the composition of test compounds and the ratio of ingredients. Multicomponent approaches should be used for treating multifactorial diseases such as obesity. As a general conclusion, there is a place for a combination of herbal components including yerba mate, based on the principle of Kun-Shin-Choa-Sa for the treatment of obesity.
Keywords
Obesity; Yerba Mate(Ilex paraguariensis); Combination; Combination effect; Combination Adverse Effect; Multicomponent; Kun-Shin-Choa-Sa;
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Times Cited By KSCI : 1  (Citation Analysis)
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