Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitory Effects of Ginseng Seed Oil on α-Glucosidase and α-Amylase Activity

인삼종자오일의 α-Glucosidase 및 α-Amylase 저해작용

  • Received : 2016.01.25
  • Accepted : 2016.03.03
  • Published : 2016.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

This study was to evaluate the effect of ginseng (Panax ginseng) seed oil on the ${\alpha}$-glucosidase and ${\alpha}$-amylase. Each ginseng seed oils (HE, SE, EE) exhibited a significant inhibitory effect (p<0.001) at all concentrations (10 and 20 mg/ml) on ${\alpha}$-glucosidase activity. HE is the highest inhibitory activity (86.92%) at a concentration of 20 mg/ml, SE and EE showed an inhibitory effect of 77.13% and 65.83%, respectively. And also, Each ginseng seed oils (HE, SE, EE) exhibited a significant inhibitory effect (p<0.001) at all concentrations (1 and 2 mg/ml) on ${\alpha}$-amylase activity. HE is the highest inhibitory activity (89.68%) at a concentration of 2 mg/ml, SE and EE showed an inhibitory effect of 76.99% and 65.70%, respectively.

Keywords

References

  1. Namba, T. (1980) The Encyclopedia of Wakan-Yaku with Color Pictures (I), 1-3, Hoikusha, Osaka.
  2. Park, J. D. (1996) Recent studies on the chemical constituents of Korean ginseng. Korean J. Ginseng Sci. 20: 389-415.
  3. Sanata, S., Kondo, N., Shoji, J., Tanaka, O. and Shibata, S. (1974) Studies on the saponins of ginseng. I. Structure of ginseng- Ro, Rb1, Rb2, Rc and Rd. Chem. Pharm. Bull. 22: 421-428. https://doi.org/10.1248/cpb.22.421
  4. Kitagawa, I., Taniyama, T., Shibuya, H., Nota, T. and Yoshikawa, M. (1987) Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root. Yakugaku Zasshi 107: 495-505. https://doi.org/10.1248/yakushi1947.107.7_495
  5. Shibata, S., Tanaka, O., Ando, T., Sado, M., Tsushima, S. and Ohsawa, T. (1966) Chemical studies on oriental plant drugs (XIV). Protopanaxadiol, a genuine sapogenin of ginseng saponins. Chem. Pharm. Bull. 14: 595-600. https://doi.org/10.1248/cpb.14.595
  6. Tanaka, O., Nagai, M. and Shibata, S. (1966) Chemical studies on the oriental plant drugs. XVI. The stereochemistry of protopanaxadiol, a genuine sapogenin of ginseng. Chem. Pharm. Bull. 14: 1150-1156. https://doi.org/10.1248/cpb.14.1150
  7. Mochizuki, M., Yoo, Y. C., Matsuzawa, K., Sato, K., Saiki, I., Tonooka, S., Samukawa, K. and Azuma, I. (1995) Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside- Rb2, 20(R)- and (S)-ginsenoside-Rg3, of red ginseng. Biol. Pharm. Bull. 18: 1197-1202. https://doi.org/10.1248/bpb.18.1197
  8. Yokozawa, T., Kobayashi, T., Oura, H. and Kawashima, Y. (1985) Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem. Pharm. Bull. 33: 869-872. https://doi.org/10.1248/cpb.33.869
  9. Takagi, K., Saito, H. and Nabata, H. (1972) Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. J. Pharmacol. 22: 245-249.
  10. Jung, I. S. and Cho, Y. D. (1985) Effect of ginseng saponin fraction on absorption of cholesterol and serum lipid components. Korean J. Ginseng Sci. 9: 232-239.
  11. Yoon, S. H. and Joo, C. N. (1993) Study on the preventive effect of ginsenosides against hypercholesterolemia and its mechanism. Korean J. Ginseng Sci. 17: 1-12.
  12. Matsuda, H., Samukawa, K. and Kubo, M. (1991) Anti-hepatitic activity of ginsenoside Ro. Planta Med. 57: 523-526. https://doi.org/10.1055/s-2006-960198
  13. Wang, B. X., Cui, J. C., Liu, A. J. and Wu, S. K. (1983) Studies on the anti-fatigue effect of the saponins of stems and leaves of Panax ginseng(SSLG). J. Tradit. Chin. Med. 3: 89-94.
  14. Saito, H., Yoshida, Y. and Tagaki, K. (1974) Effects of Panax ginseng root on exhaustive exercise in mice. Jpn J. Pharmacol. 24: 119-126. https://doi.org/10.1254/jjp.24.119
  15. Jeong, C. S., Hyun, J. E. and Kim, Y. S. (2002) Anti-oxidative effect of ginsenoside Rb1 on the HCl ethanol-induced gastric tissue in rats. Korean J. Pharmacogn. 33: 252-256.
  16. Matsuda, H., Samukawa, K. and Kubo, M. (1990) Antiinflammatory activity of ginsenoside Ro. Planta Med. 56: 19-23. https://doi.org/10.1055/s-2006-960875
  17. Yokozawa, T., Oura, H. (1990) Facilitation of protein biosynthesis by ginsenoside-Rb2 administration in diabetic rats. J. Nat. Prod. 53: 1514-1518. https://doi.org/10.1021/np50072a018
  18. Jie, Y. H., Cammisuli, S. and Baggiolini, M. (1984) Immunomodulatory effects of Panax ginseng C.A. Meyer in the mouse. Agents Actions 15: 386-391. https://doi.org/10.1007/BF01972376
  19. Jeon, B. S., Choi, K. J., Sung, H. S., Chang, K. S. and Koh, S. R. (1995) Effect of controlled atmosphere and modified atmosphere storage on the fatty acid of fresh and red ginseng. Korean J. Ginseng Sci. 19: 260-266.
  20. Zhang, X. J., Huang, L. L., Cai, X. J., Li, P., Wang, Y. T. and Wan, J. B. (2013) Fatty acid variability in three medicinal herbs of Panax species. Chem. Cent. J. 7: 7-12. https://doi.org/10.1186/1752-153X-7-7
  21. Ko, Y. S. and Chung, B. S. (1981) Studies on the oil soluble constituents of Korean ginseng. Korean J. Food Sci. Technol. 13: 15-19.
  22. Zhu, X. M., Hu, J. N., Shin, J. A., Lee, J. H., Hong, S. T. and Lee, K. T. (2010) Comparison of seed oil characteristics from Korean ginseng, Chinese ginseng (Panax ginseng C.A. Meyer) and American ginseng (Panax quinquefolium L.). J. Food Sci. Nutr. 15: 275-281.
  23. Korea Food and Drug Administration. (2001) Code of Korea Food Regulation 2001. 257-265, Korea Food and Drug Administration, Seoul.
  24. Lee, K. Y., Hong, S. Y., Jeong, H. J., Lee, J. H., Lim, S. H., Heo, N. K., Kim, S. M. and Kim, H. Y. (2014) Isolation and identification of ${\alpha}$-glucosidase inhibitory compounds, hyperoside, and isoquercetin from Eleutherococcus senticosus Leaves. J. Korean Soc. Food Sci. Nutr. 43: 1858-1864. https://doi.org/10.3746/jkfn.2014.43.12.1858
  25. Kim, D. Y., Jung, J. Y., Kim, K. B. W. R., Lee, C. J., Kwak, J. H., Kim, M. J., Woo, C. S., Kim, H. J., Jung, S. A., Kim, T. W., Cho, Y. J. and Ahn, D. H. (2011) Effects of heat and pH treatments on ${\alpha}$-amylase inhibitory activity of Ecklonia cava ethanol extract. Kor. J. Fish Aquat. Sci. 44: 791-795.
  26. Wolanska, D. and Klosiewicz-Latoszek L. (2012) Fatty acids intake and serum lipids profile in overweighted and obese adults. Rocz Panstw Zakl Hig 63: 155-162.
  27. Wanders, A. J., Brouwer, I. A., Siebelink, E. and Katan, M. B. (2010) Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects. PLoS 5: e9000. https://doi.org/10.1371/journal.pone.0009000