생약학회지 (Korean Journal of Pharmacognosy)

  • 제47권1호
  • /
  • Pages.1-6
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  • 2016
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

히어리나무의 페놀성 화합물 및 세포독성활성

Phenolic Compounds from the Twigs of Corylopsis coreana Uyeki and Their Cytotoxic Activity

  • 권오길 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 김충섭 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 서원세 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 박경진 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 차준민 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 최상운 (한국화학연구원) ;
  • 권학철 (한국과학기술연구원 천연물연구소) ;
  • 이강노 (성균관대학교 약학대학 천연물약품화학연구실)
  • Kwon, Oh Kil (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Chung Sub (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Suh, Won Se (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Park, Kyoung Jin (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Cha, Joon Min (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Choi, Sang Un (Korea Research Institute of Chemical Technology) ;
  • Kwon, Hak Cheol (Natural Product Research Center, Korea Institute of Science and Technology) ;
  • Lee, Kang Ro (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
  • 투고 : 2016.02.04
  • 심사 : 2016.03.18
  • 발행 : 2016.03.31
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초록

Phytochemical investigation of the twigs of Corylopsis coreana afforded 10 phenolic compounds, bergenin (1), 6'-O-galloylbergenin (2), 3'-O-galloylbergenin (3), (-)-catechin (4), (-)-epicatechin (5), (-)-epicatechin-3-O-galloyl ester (6), 4-methoxy-3,-5-dihydroxybenzoic acid (7), gallic acid (8), 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-glucopyranoside (9), and 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-(6-O-galloyl)-glucopyranoside (10). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. The compounds 3, 9 and 10 were isolated for the first time from this source. All the isolates (1-10) were tested for their cytotoxic activity against A549, SK-OV-3, SK-MEL-2, and HCT15 cell lines in vitro using the SRB bioassay. The compounds 5, 7 and 8 exhibited selective cytotoxic activity against SK-MEL-2 cell line.

키워드

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