Browse > Article

Phenolic Compounds from the Twigs of Corylopsis coreana Uyeki and Their Cytotoxic Activity  

Kwon, Oh Kil (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
Kim, Chung Sub (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
Suh, Won Se (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
Park, Kyoung Jin (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
Cha, Joon Min (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
Choi, Sang Un (Korea Research Institute of Chemical Technology)
Kwon, Hak Cheol (Natural Product Research Center, Korea Institute of Science and Technology)
Lee, Kang Ro (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
Publication Information
Korean Journal of Pharmacognosy / v.47, no.1, 2016 , pp. 1-6 More about this Journal
Abstract
Phytochemical investigation of the twigs of Corylopsis coreana afforded 10 phenolic compounds, bergenin (1), 6'-O-galloylbergenin (2), 3'-O-galloylbergenin (3), (-)-catechin (4), (-)-epicatechin (5), (-)-epicatechin-3-O-galloyl ester (6), 4-methoxy-3,-5-dihydroxybenzoic acid (7), gallic acid (8), 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-glucopyranoside (9), and 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-(6-O-galloyl)-glucopyranoside (10). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. The compounds 3, 9 and 10 were isolated for the first time from this source. All the isolates (1-10) were tested for their cytotoxic activity against A549, SK-OV-3, SK-MEL-2, and HCT15 cell lines in vitro using the SRB bioassay. The compounds 5, 7 and 8 exhibited selective cytotoxic activity against SK-MEL-2 cell line.
Keywords
Corylopsis coreana; Hamamelidaceae; Bergenin; Flavonoid; Cytotoxicity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kim, M. H., Ha, S. Y., Oh, M. H., Kim, H. H., Kim, S. R. and Lee, M. W. (2013) Anti-oxidative and anti-proliferative activity on human prostate cancer cells lines of the phenolic compounds from Corylopsis coreana Uyeki. Molecules 18: 4876-4886.   DOI
2 Iwashina, T., Kitajima, J. and Takemura, T. (2012) Flavonoids from the leaves of six Corylopsis species (Hamamelidaceae). Biochem. Syst. Ecol. 44: 361-363.   DOI
3 Skehan, P., Stroreng, R., Scudiero, D., Monks, A., Mcmahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S. and Boyd, M. R. (1990) New colorimetric cytotoxicity assay for anti-cancer-drug screening. J. Natl. Cancer Inst. 82: 1107-1112.   DOI
4 Nunomura, R. C. S., Oliveira, V. G., Da Silva, S. L. and Nunomura, S. M. (2009) Characterization of bergenin in Endopleura uchi bark and its anti-inflammatory activity. J. Braz. Chem. Soc. 20: 1060-1064.   DOI
5 이창복 (2003) 원색대한식물도감, 500. 향문사, 서울.
6 박종희 (2004) 한국약초도감, 636. 신일상사, 서울.
7 Patel, D. K., Patel, K., Kumar, R., Gadewar, M. and Tahilyani, V. (2012) Pharmacological and analytical aspects of bergenin: a concise report. Asian Pac. J. Tro. Dis. 163-167
8 Sariga, C. D., Shakila, R. and Kothai, S. (2015) Isolation, characterization and quantification of bergenin from Syzygium cumini stem bark. Int. Res. J. Pharm. 6: 108-110.   DOI
9 Taneyama, M., Yoshida, S., Kobayashi, M. and Hasegawa, M. (1983) Isolation of norbergenin from Saxifraga stolonifera. Phytochemistry 22: 1053-1054.   DOI
10 Yoshida, T., Takama, T. and Okuda, T. (1982) Bergenin derivatives from Mallotus japonicas. Phytochemistry 20: 1180-1182.
11 Hongmei, P., Bin, C., Fu, L. and Mingkui, W. (2013) Chemical constituents from the stems of Dendrobium denneanum (ll). Chin. J. Appl. Environ Biol. 19: 952-955.   DOI
12 Nonaka, G., Nishimura, H. and Nishioka, I. (1982) Tannins and related compounds. IV. seven new phenol glucoside gallates from Quercuss tenphylla MAKINO (1). Chem. Pharm. Bull. 30: 2061-2067.   DOI
13 Lin, H. Y., Kuo, Y. H., Lin, Y. L. and Chiang, W. C. (2009) Antioxidative Effect and active components from leaves of Lotus (Nelumbo nucifera). J. Agric. Food Chem. 57: 6623-6629.   DOI
14 Foo, L. Y., Lu, Y., Howell, A. B. and Vorsa, N. (2000) The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry 54: 173-181.   DOI
15 Braca, A., Politi, M., Sanogo, R., Sanou, H., Morelli, I., Pizza, C. and De Tommasi, N. (2003) Chemical composition and antioxidant activity of phenolic compounds from wild and cultivated Sclerocarya birrea (Anacardiaceae) leaves. J. Agric. Food Chem. 51: 6689-6695.   DOI
16 Saxena, G., McCutcheon, A. R., Farmer, S. Towers, G. H. N. and Hancock, R. E. W. (1994) Antimicrobial constituents of Rhus glabra. J. Ethnopharmacol. 42: 95-99.   DOI
17 Ning, D. S., Yan, X. X., Huang, S. S., Cheng, L., Li, J. and Pan, Z. H. (2015) Studies on chemical constituents of zhuang medicine Excoecaria venenata and their cytotoxic activity. Chn. J. Chin. Mat. Med. 40: 686-690.