생약학회지 (Korean Journal of Pharmacognosy)

  • 제47권1호
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  • Pages.7-11
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  • 2016
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

괄루경엽의 BV2 미세아교세포에서의 항염증 활성 성분

Anti-inflammatory Constituents of the Aerial Parts of Trichosanthes kirilowii in BV2 Microglial Cells

  • 리소군 (원광대학교 약학대학 약품연구소) ;
  • 김관우 (원광대학교 약학대학 약품연구소) ;
  • 고원민 (원광대학교 약학대학 약품연구소) ;
  • 김동철 (원광대학교 약학대학 약품연구소) ;
  • 윤치수 (원광대학교 약학대학 약품연구소) ;
  • 유향전 (후난중의약대학) ;
  • 김종수 (원광대학교 약학대학 약품연구소) ;
  • 장규관 (원광대학교 자연식물원) ;
  • 강대길 (원광대학교 한방체액조절센터) ;
  • 이호섭 (원광대학교 한방체액조절센터) ;
  • 오현철 (원광대학교 약학대학 약품연구소) ;
  • 김윤철 (원광대학교 약학대학 약품연구소)
  • Li, Xiao Jun (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Kwan-Woo (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Ko, Wonmin (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Dong-Cheol (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Yoon, Chi-Su (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Liu, Xiang Qian (School of Pharmacy, Hunan University of Chinese Medicine) ;
  • Kim, Jong-Su (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Jang, Kyu-Kwan (Natural Botanical Garden, Wonkwang University) ;
  • Kang, Dae-Gil (Hanbang Body-Fluid Research Center, Wonkwang University) ;
  • Lee, Ho-Sub (Hanbang Body-Fluid Research Center, Wonkwang University) ;
  • Oh, Hyuncheol (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
  • 투고 : 2016.02.16
  • 심사 : 2016.03.28
  • 발행 : 2016.03.31
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초록

The aerial part of Trichosanthes kirilowii Maxim. (Cucurbitaceae), has long been used in traditional Korean and Chinese medicines for the treatment of heatstroke. We isolated and identified three flavones, luteolin-7-O-${\beta}$-D-glucopyranoside(1), luteolin-4'-O-${\beta}$-D-glucopyranoside(2), luteolin(3) from its methanolic extract. In the present study, we found that luteolin attenuates the lipopolysaccharide(LPS)-induced inflammation in BV2 microglial cells. Luteolin significantly inhibited LPS-induced production of pro-inflammatory mediators such as nitric oxide(NO) and prostaglandin $E_2(PGE_2)$ in BV2 microglia in a concentration-dependent manner without cytotoxic effect. Luteolin dose-dependently suppressed the protein expression of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2). In addition, luteolin also showed significant induction of heme oxygenase(HO)-1. These results suggest that both the aerial part of T. kirilowii and luteolin may be good candidates to regulate LPS-induced inflammatory response.

키워드

참고문헌

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