Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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A Case of Necrotizing Meningoencephalitis in a Shih-Tzu Dog

시츄견의 괴사성 뇌막뇌염 증례 보고

  • Jung, Ji-Youl (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Yun, Young-Min (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 정지열 (제주대학교 수의과대학, 수의과학연구소) ;
  • 윤영민 (제주대학교 수의과대학, 수의과학연구소) ;
  • 김재훈 (제주대학교 수의과대학, 수의과학연구소)
  • Accepted : 2015.10.17
  • Published : 2016.02.29
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Abstract

Necrotizing meningoencephalitis (NME) is a unique idiopathic nonsuppurative inflammatory disease of central nervous system in small-sized breed dogs. A 9-year-old intact male Shih-Tzu dog with anorexia, vomiting, salivation and intermittent seizures was submitted to the Jeju National University for diagnosis. Grossly, there were no obvious lesions in the brain, except dilatation of most blood vessels in meninges. Histopathologically, brain revealed severe multifocal nonsuppurative inflammation in perivascular area of meninges and cerebral cortex. Some areas of cerebral parenchyma were replaced with lots of macrophages contained periodic acid-Schiff positive materials. Many new-formed blood vessels were observed around the necrotic regions using Gomori reticulum stain. Immunohistochemistry and reverse transcription-polymerase chain reaction were negative for toxoplasmosis and canine distemper virus. Based on the gross, histopathologic features and antigen detection methods, this case was diagnosed as NME. Here we reported the NME in relatively uncommon breed, Shih-Tzu dog, than other small breed dogs.

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References

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