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http://dx.doi.org/10.17555/jvc.2016.02.33.1.70

A Case of Necrotizing Meningoencephalitis in a Shih-Tzu Dog  

Jung, Ji-Youl (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Yun, Young-Min (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Kim, Jae-Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Publication Information
Journal of Veterinary Clinics / v.33, no.1, 2016 , pp. 70-73 More about this Journal
Abstract
Necrotizing meningoencephalitis (NME) is a unique idiopathic nonsuppurative inflammatory disease of central nervous system in small-sized breed dogs. A 9-year-old intact male Shih-Tzu dog with anorexia, vomiting, salivation and intermittent seizures was submitted to the Jeju National University for diagnosis. Grossly, there were no obvious lesions in the brain, except dilatation of most blood vessels in meninges. Histopathologically, brain revealed severe multifocal nonsuppurative inflammation in perivascular area of meninges and cerebral cortex. Some areas of cerebral parenchyma were replaced with lots of macrophages contained periodic acid-Schiff positive materials. Many new-formed blood vessels were observed around the necrotic regions using Gomori reticulum stain. Immunohistochemistry and reverse transcription-polymerase chain reaction were negative for toxoplasmosis and canine distemper virus. Based on the gross, histopathologic features and antigen detection methods, this case was diagnosed as NME. Here we reported the NME in relatively uncommon breed, Shih-Tzu dog, than other small breed dogs.
Keywords
brain; cerebral cortex; necrotizing meningoencephalitis; nonsuppurative inflammation; Shih-Tzu dog;
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