Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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A Effect of Photo Dynamic Therapy for LAZER Wave Mode

방사모드에 따른 레이저 치료 효과

  • Choi, Deog Su (Department of Biomedical Engineering, College of Medicine, Chungnam National University) ;
  • Lim, Hyun Soo (Department of Biomedical Engineering, College of Medicine, Chungnam National University) ;
  • Lee, Byung Koo (Department of Biomedical Engineering, College of Medicine, Chungnam National University) ;
  • Kenar, Necla (Department of Biomedical Engineering, College of Medicine, Chungnam National University)
  • 최덕수 (충남대학교 의과대학 의공학교실) ;
  • 임현수 (충남대학교 의과대학 의공학교실) ;
  • 이병구 (충남대학교 의과대학 의공학교실) ;
  • 네클라 커나르 (충남대학교 의과대학 의공학교실)
  • Received : 2016.07.18
  • Accepted : 2016.08.23
  • Published : 2016.08.31
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Abstract

US Food and Drug Administration (FDA) approved as a innovative cure for cancer, 1996. The effect is death of cancer cells through necrosis, apoptosis. Mainly the Continuous Wave mode (CW) use for PDT Laser. It sting, the question including itch, and etc. Reportedly, the increase of temperature with the perforated edema, ulcer, necrosis. The Thermal relaxation time and Oxygen recovery time is necessary. To give a normal oxygen recovery time of the cell, used Pulse mode. Progress, it was Burst Pulse mode when easing the thermal wake, the simplicity was secured, the PDT effect is good. Excepted in control group CW, Pulse, Burst pulse mode were incubated with various concentrations of 5-aminolevulinic acid hydrochloride (ALA-5). The tumor size reduction CW mode (44%), Pulse mode (48%), Burst pulse mode (53%) at 4 week after PDT with 0.3, 0.3, 0.3 mg/ml of ALA-5. After 4 hours, investigation of 100, 100, $100J/cm^2$ laser irradiation. The pulse mode was superior in expirimental data analysis. And it was the Burst pulse mode edge head of a family effect.

Keywords

References

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