Journal of the Korea Institute of Military Science and Technology (한국군사과학기술학회지)

The Korea Institute of Military Science and Technology (한국군사과학기술학회)
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Whole Transcriptomic Analysis of Bacillus anthracis during Hydrogen Peroxide Decontamination

과산화수소 제독 과정에서의 탄저균 전사체 분석

  • Kim, Sang Hoon (Department of Molecular and Life Science, Hanyang University) ;
  • Kim, Se Kye (Department of Molecular and Life Science, Hanyang University) ;
  • Jung, Kyoung Hwa (Department of Molecular and Life Science, Hanyang University) ;
  • Yoon, Sung Nyo (Department of Molecular and Life Science, Hanyang University) ;
  • Kim, Yun Ki (Department of Molecular and Life Science, Hanyang University) ;
  • Kim, Min Cheol (Department of Molecular and Life Science, Hanyang University) ;
  • Ryu, Sam Gon (The 5th Research and Development Institute, Agency for Defense Development) ;
  • Lee, Hae Wan (The 5th Research and Development Institute, Agency for Defense Development) ;
  • Chai, Young Gyu (Department of Molecular and Life Science, Hanyang University)
  • 김상훈 (한양대학교 분자생명과학과) ;
  • 김세계 (한양대학교 분자생명과학과) ;
  • 정경화 (한양대학교 분자생명과학과) ;
  • 윤성녀 (삼양화학공업(주) 분석기기연구소) ;
  • 김윤기 (삼양화학공업(주) 분석기기연구소) ;
  • 김민철 (삼양화학공업(주) 분석기기연구소) ;
  • 류삼곤 (국방과학연구소 제5기술연구본부 화생방부) ;
  • 이해완 (국방과학연구소 제5기술연구본부 화생방부) ;
  • 채영규 (한양대학교 분자생명과학과)
  • Received : 2015.02.04
  • Accepted : 2015.07.24
  • Published : 2015.08.05
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Abstract

Decontamination of biological agents utilizes hydrogen peroxide($H_2O_2$) for its effectiveness and safeness. Bacillus anthracis is a major target for $H_2O_2$ decontamination. To assess the effect of $H_2O_2$ on B. anthracis and identify biomarkers for decontamination, whole transcriptomic profiling of $H_2O_2$-treated B. anthracis was performed. Here we identified deregulation in stress response genes, transcription factors and cellular homeostasis genes. We also found that expression of antisense RNAs increased in B. anthracis during decontamination. We postulate that B. anthracis prioritizes survival and adaptation in response to $H_2O_2$ treatment by changing its gene expression pattern.

Keywords

References

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