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http://dx.doi.org/10.9766/KIMST.2015.18.4.478

Whole Transcriptomic Analysis of Bacillus anthracis during Hydrogen Peroxide Decontamination  

Kim, Sang Hoon (Department of Molecular and Life Science, Hanyang University)
Kim, Se Kye (Department of Molecular and Life Science, Hanyang University)
Jung, Kyoung Hwa (Department of Molecular and Life Science, Hanyang University)
Yoon, Sung Nyo (Department of Molecular and Life Science, Hanyang University)
Kim, Yun Ki (Department of Molecular and Life Science, Hanyang University)
Kim, Min Cheol (Department of Molecular and Life Science, Hanyang University)
Ryu, Sam Gon (The 5th Research and Development Institute, Agency for Defense Development)
Lee, Hae Wan (The 5th Research and Development Institute, Agency for Defense Development)
Chai, Young Gyu (Department of Molecular and Life Science, Hanyang University)
Publication Information
Journal of the Korea Institute of Military Science and Technology / v.18, no.4, 2015 , pp. 478-483 More about this Journal
Abstract
Decontamination of biological agents utilizes hydrogen peroxide($H_2O_2$) for its effectiveness and safeness. Bacillus anthracis is a major target for $H_2O_2$ decontamination. To assess the effect of $H_2O_2$ on B. anthracis and identify biomarkers for decontamination, whole transcriptomic profiling of $H_2O_2$-treated B. anthracis was performed. Here we identified deregulation in stress response genes, transcription factors and cellular homeostasis genes. We also found that expression of antisense RNAs increased in B. anthracis during decontamination. We postulate that B. anthracis prioritizes survival and adaptation in response to $H_2O_2$ treatment by changing its gene expression pattern.
Keywords
Bacillus anthracis; Transcrptome; Hydrogen Peroxide; Decontamination;
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Times Cited By KSCI : 1  (Citation Analysis)
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