Asian Pacific Journal of Cancer Prevention

  • 제16권13호
  • /
  • Pages.5319-5323
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Prognostic Factors in Oligodendrogliomas: a Clinical Study of Twenty-Five Consecutive Patients

  • Atalay, Tugay (Department of Neurosurgery, School of Medicine, Bozok University) ;
  • Ak, Hakan (Department of Neurosurgery, School of Medicine, Bozok University) ;
  • Celik, Bahattin (Department of Neurosurgery, School of Medicine, Harran University) ;
  • Gulsen, Ismail (Department of Neurosurgery, School of Medicine, Yuzuncu Yil University) ;
  • Seckin, Hakan (Department of Neurosurgery, Lokman Hekim Private Hospital) ;
  • Tanik, Nermin (Department of Neurology, School of Medicine, Bozok University) ;
  • Albayrak, Sedat Baki (Department of Neurosurgery, School of Medicine, Suleyman Demirel University) ;
  • Bavbek, Murad (Department of Neurosurgery, School of Medicine, Yildirim Beyazit University)
  • 발행 : 2015.08.03
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초록

Background: The purpose of this study was to evaluate the prognostic significance of Ki-67 and subjective microvascular density (SMVD) indexes together with other factors in patients with oligodendroglioma. Materials and Methods: In this retrospective study, oligodendroglioma specimens obtained from twenty-five consecutive patients were evaluated for Ki-67 and SMVD indices to help determine histological grading and investigate the fidelity of these markers in clinical prognosis. Other potentially prognostic factors were Karnofsky performance scale, tumor histological grade, and adjuvant radiotherapy. Results: The Ki-67 proliferation index appeared to have a strong correlation with the grade of the tumor and the survival. Age, gender, adjuvant radiotherapy, surgical resection type (complete versus incomplete) did not have any influence on recurrence. The SMVD index correlated significantly with the 3 to 5-year survival. Conclusions: Ki-67 and MVD indexes are important and useful markers in estimating the prognosis of oligodendrogliomas.

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참고문헌

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