Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Autophagy in Tumorigenesis and Cancer Treatment

  • Xu, Dong-Wei (Department of Chinese Minority Traditional Medicine, Minzu University of China) ;
  • Zhang, Guan-Qing (Department of Chinese Minority Traditional Medicine, Minzu University of China) ;
  • Wang, Zong-Wei (Department of Urology, Massachusetts General Hospital) ;
  • Xu, Xiao-Yin (Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School) ;
  • Liu, Tong-Xiang (Department of Chinese Minority Traditional Medicine, Minzu University of China)
  • Published : 2015.04.03
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Abstract

Autophagy is a self-digestion process, wrapping cytoplasmic proteins or organelles to form vesicles for degradation in lysosomes. The process plays an important role in the maintenance of intracellular homostasis. Here we overview articles on autophagy and cancer/tumors in Pubmed and found 327 articles. Autophagy exists in many tumors and is involved in cell malignant transformation and tumor cell growth. In early phases of tumorigenesis, autophagy clears the abnormally folded proteins and dysfunctional organelles such as mitochondria. Autophagy can also inhibit cell stress responses and prevent genetic damage. When a tumor develops, autophagy helps tumor cells survive nutritional deficiencies and hypoxic conditions. Studies of autophagy in the occurrence and progression of tumors should provide new therapeutic strategies for tumors.

Keywords

References

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