한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제32권4호
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  • Pages.352-355
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  • 2015
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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복제를 통한 우수한 암탐지 능력의 보존

Preservation through Cloning of Superior Canine Scent Detection Ability for Cancer Screening

  • 김민정 (서울대학교 수의학과 수의산과 및 생명공학) ;
  • 박정은 (미국 국립보건원, 국립 신경질환 및 뇌졸중 연구소) ;
  • 오현주 (서울대학교 수의학과 수의산과 및 생명공학) ;
  • 홍소군 (미국 국립보건원, 국립 심장, 폐, 혈액 연구소) ;
  • 강정택 (지아이블루) ;
  • 임상현 ;
  • 이동원 ;
  • 라정찬 ;
  • 이병천 (서울대학교 수의학과 수의산과 및 생명공학)
  • Kim, Min-Jung (College of Veterinary Medicine, Seoul National University) ;
  • Park, Jung-Eun (Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health) ;
  • Oh, Hyun-Ju (College of Veterinary Medicine, Seoul National University) ;
  • Hong, So-Gun (Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health) ;
  • Kang, Jung-Taek (GIBLUE Biotechnology Research Institute) ;
  • Rhim, Sang-Hyun (K-Stem Cell) ;
  • Lee, Dong-Won (K-Stem Cell) ;
  • Ra, Jung-Chan (K-Stem Cell) ;
  • Lee, yeong-Chun (College of Veterinary Medicine, Seoul National University)
  • 심사 : 2015.03.27
  • 발행 : 2015.08.31
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초록

본 연구는 암탐지에 우수한 능력을 보유하고 있는 공여견의 냄새 탐지 능력이 복제를 통하여 보존될 수 있을지를 알아보기 위하여 설계되었다. 직장암 탐지에 특화되어 훈련된 개를 복제하였고, 복제된 개는 환자와 건강한 지원자들로부터 채취된 호흡 샘플을 사용하여 유방암을 탐지하도록 훈련 되었다. 복제개의 암탐지 민감도는 93.3%, 특이도는 99.5%로 공여견의 암탐지 민감도 및 특이도 (91% 및 99%)와 유사하였다. 게다가 복제개는 유방암의 초기 단계까지 성공적으로 탐지할 수 있었다. 따라서 우수한 암탐지 능력은 복제를 통해서 보존될 수 있을 것이다.

This study was conducted to ascertain whether the scent detection ability of a donor dog having extraordinary talent in cancer detection can be conserved through cloning. A specially trained dog for colorectal cancer detection was cloned, and she was trained and tested to detect breast cancers using breath samples collected from patients and healthy volunteers. Scent detection sensitivity of the clone was 93.3% and specificity was 99.5%, similar with those of donor (91% and 99%). Furthermore, the clone successfully detected early stage of breast cancers. Therefore, superior canine scent detection ability for cancer screening could be preserved through cloning.

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