Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Whitening Effect of Salicornia herbacea Ethanol Extract by Inhibition of Melanin Synthesis

함초 에탄올 추출물의 멜라닌 합성 억제를 통한 미백 효과

  • Received : 2015.07.24
  • Accepted : 2015.10.30
  • Published : 2015.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

This study was carried out to investigate the effect of ethanolic extract Salicornia herbacea (SHEE) on melanogenesis and mechanism. The SHEE on ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH) induces melanogenesis in B16F10 melanoma cells. The effect of SHEE remarkably decreased protein expression of tyrosinase and tyrosinase relate protein (TRP)-2 increased extracellular signal related kinase (ERK) on ${\alpha}$-MSH 100 nM induced melanogenesis on B16F10 melanoma cells at dose-dependent manner. It has been reported that the activation of ERK reduce melanin synthesis by down-regulating micro-phthalmia-associated transcription fator (MITF). These results sugggest that possibility of extracted korean medicinal herbs as a functional ingredient for whitening cosmetic formula.

Keywords

References

  1. Seo, E. J., Hong, E. S., Choi, M. H., Kim. K. S. and Lee, S. J. (2010) Antioxidant and skin whitening effects of Rhamnus yoshinoi extracts. J. korea. Food. Sci. 42: 750-754
  2. Lee, S. Y., Jun, H. J., Lee, I. C. and Lee, J. Y. (2013) Downregulation of tyrosinase, MITF, TRP-1 and TRP-2 expressions by Juniperus rigida Sieb in Murine B16F10 Melanoma. J. life sci. 23: 1445-1453. https://doi.org/10.5352/JLS.2013.23.12.1445
  3. Widlund, H. R. and Fisher. D. E. (2003) Microphthalamia a sociated transcription factor: a acritical regulator of pigment cell development and survival. Oncogene 22: 30-35.
  4. Im, S. B., Lee, E. S., Kim, W. K., On, W. Y., Kim, W. Y. and Lee, J. H. (2002) Donor specific response of estrogen and progesterone on cultured human melanocyte. J. Kor. Med. Sci. 17: 58-64. https://doi.org/10.3346/jkms.2002.17.1.58
  5. Lee, H. H., Bae, S. and Chin, J. E. (2005) Inhibitory effect of Lithosppermum erythrarhizon extracts on melanin biosynthesis. J. Korean soc. Food Sci. Nutr. 34: 1325-1329. https://doi.org/10.3746/jkfn.2005.34.9.1325
  6. Hwang, J. Y., Park, T. S. and Son, J. H. (2013) Whitening effect of extracts and fractions from Diospyros kaki Calyx. J. Life Sci. 23: 383-388. https://doi.org/10.5352/JLS.2013.23.3.383
  7. Ihm, B. S. and Lee, J. S. (1986) The strategies of Salicornia herbacea and Suaeda japonica for coping with environmental fluctuation of salt marsh. Korean J. Environ. Biol. 4: 15-25.
  8. Min, J. G., Lee, D. S. Kim, T. J., Park, J. H., Cho, T. Y. and Park, D. I. (2002) Chemical composition of Salicornia herbacea L. J. Food Sci. Nutr. 7: 105-107. https://doi.org/10.3746/jfn.2002.7.1.105
  9. Im, S. A., Kim, G. W. and Lee, C. K. (2003) Immunodulatory activity of Salicornia herbacea L. components. Nat. Prod. Sci. 9: 273-277.
  10. Ahn, B. K., Kim, R., Choi, D. B. and Kim, Y. S. (2011) Effect of Salicornia bigelovii extract on the activities of whitening and anti-wrinkle. Appl. Chem. Eng. 22: 56-60.
  11. Sakuma, K., Ogawa, M., Sugibayashi, K., Yamada, K. and Yamamoto, K. (1999) Relation between tyrosinase inhibitory action and oxidation-reduction potential of cosmetic whitening ingredients and phenol derivatives. Arch. Pharm. Res. 22: 335-339. https://doi.org/10.1007/BF02979054
  12. del Marmol, V. and Beermann, F. (1996) Tyrosinase and related proteins in mamalian pigmentation. FEBS. Lett. 381: 165-168. https://doi.org/10.1016/0014-5793(96)00109-3
  13. Park, H. J., Kwon, E. J., Kim, E. J., Lee, K. R., Il, H., Lee, D. G. and Oh, Y. H. (2014) Whitening effect of Poria cocas ethnol extract by inhibition of melanin synthesis. J. Life Sci. 24: 485-490. https://doi.org/10.5352/JLS.2014.24.5.485
  14. Lee, H. E., Kim, E. H., Choi, H. R., Sohn, U. D., Yun, H. Y., Baek, K. J., Kwon, N. S., Park, K. C. and Kim, D. S. (2012) Dipeptides inhibit melanin synthesis in Mel-Ab cells through down-regulation of tyrosinase. J. Korean Phy. Pharmacol. 16: 287-291. https://doi.org/10.4196/kjpp.2012.16.4.287
  15. Kim, Y. A., Park, S. H., Kim, B. Y., Kim, A. H., Park, B. J. and Kim, J. J. (2014) Inhibitory effects on melanin production of demethylsuberosin isolated from Angelica gigas Nakai. Kor. J. Pharmacogn. 45: 209-213.
  16. Jeong, Y. M., OH, W. K., Tien Lam Tran, Kim, W. K., Sung, S. H., Bae, K. Y., Lee, S. M. and Sung, J. H. (2013) Aglycone of Rh4 inhibits melanin synthesis in B16 melanoma cells: possible involvement of the protein kinase A pathway. BioSci. Biotechnol. Biochem. 77: 119-125. https://doi.org/10.1271/bbb.120602
  17. Kim, D. S., Hwang, J. E., Lee, S. Y., Kim, S. B., Kwon. and Park, K. C. (2003) Sphingosine-1-phosphate decrease melanin synthesis via sustained ERK activation and subsequent MITF degradation. J. Cell Sci. 116: 1699-1706. https://doi.org/10.1242/jcs.00366
  18. Busca, R. and Ballotti, R. (2000) Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigm. Cell Res. 13: 60-69. https://doi.org/10.1034/j.1600-0749.2000.130203.x
  19. Chia, H. L., Chou, T. H. Tseng, Y. P. and Ding, H. Y. (2012) Trans-caffeic acid stearyl ester from Paeonia suffruticosa inhibits melanin synthesis by cAMP-mediating down-regulation of ${\alpha}$-melanocyte-stimulating hormone-stimulated melanogenesis signaling pathway in B16 cells. Biol. Pharm. Bull. 35: 2198-2203. https://doi.org/10.1248/bpb.b12-00619
  20. Joung, H. S., Kyung, H. S. and Kim, A. K. (2007) Anti-melanogenic effect of taurine in murine melanoma B16F10 cells. Yakhak Hoeji 51: 350-354.