Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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n-Butanol Extract of Mulberry Leaves Suppresses LPS-induced Inflammatory Cytokines and Modulates Osteogenic Differentiation in Periodontal Ligament Cells

뽕잎 n-부탄올 추출물의 치주인대세포에서 LPS로 유도된 염증성 사이토카인의 억제와 골 형성 분화 조절

  • Choi, Jeong Lee (Division of Oral and Maxillofacial Surgery, Department of Dentistry, Ajou University School of Medicine) ;
  • Kim, Dae Keun (College of Pharmacy, Woosuk University) ;
  • Kim, Eun Hee (Department of dental Hygiene Gangneung Yeongdong University) ;
  • Lee, Jeong Keun (Division of Oral and Maxillofacial Surgery, Department of Dentistry, Ajou University School of Medicine)
  • Received : 2015.11.14
  • Accepted : 2015.11.24
  • Published : 2015.12.31
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Abstract

Periodontitis is a chronic inflammatory disease that is known to have the characteristics of destructed periodontal tissue. Anti-oxidant and anti-inflammatory effects of mulberry leaves in periodontal tissue is not well known until now. We investigated the effects of n-butanol extract of mulberry leaves on the lipopolysaccharide (LPS)-induced proinflammatory cytokines, such as $IL-1{\beta}$, IL-6, IL-8 and modulates osteogenic differentiation in periodontal ligament cells. The expression levels of Runx2, ALP and mRNA were increased by n-butanol extract of mulberry leaves at the concentration of $100{\mu}g/ml$ in periodontal ligament cells. n-Butanol extract of mulberry leaves extract reduced the range of pathophysiological processes, such as inflammation and increase in the level of osteogenic-related genes. These findings suggest that n-butanol extract of mulberry leaves has therapeutic effects on periodontitis and periodontal tissue regeneartion.

Keywords

References

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