Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Deuteromethylactin B from a Freshwater-derived Streptomyces sp.

  • Shaikh, Anam F. (Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago) ;
  • Elfeki, Maryam (Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago) ;
  • Landolfa, Samantha (Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago) ;
  • Tanouye, Urszula (Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago) ;
  • Green, Stefan J. (Department of Biological Sciences, University of Illinois at Chicago) ;
  • Murphy, Brian T. (Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago)
  • Received : 2015.07.04
  • Accepted : 2015.08.13
  • Published : 2015.12.31
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Abstract

Compared to their terrestrial and marine counterparts, little is known about the capacity of freshwater-derived actinomycete bacteria to produce novel secondary metabolites. In the current study, we highlight the disparities that exist between cultivation-independent and -dependent analyses of actinomycete communities from four locations in Lake Michigan sediment. Furthermore, through phylogenetic analysis of strains isolated from these locations, we identified a Streptomyces sp., strain B025, as being distinct from other Streptomyces spp. isolated from sediment. Upon fermentation this strain produced a rare class of eight-membered lactone secondary metabolites, which have been for their antitumor properties. We used spectroscopic and chemical derivitization techniques to characterize octalactin B (1) in addition to its corresponding novel, unnatural degradation product (2).

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