• Title/Summary/Keyword: Octalactin

Search Result 1, Processing Time 0.014 seconds

Deuteromethylactin B from a Freshwater-derived Streptomyces sp.

  • Shaikh, Anam F.;Elfeki, Maryam;Landolfa, Samantha;Tanouye, Urszula;Green, Stefan J.;Murphy, Brian T.
    • Natural Product Sciences
    • /
    • v.21 no.4
    • /
    • pp.261-267
    • /
    • 2015
  • Compared to their terrestrial and marine counterparts, little is known about the capacity of freshwater-derived actinomycete bacteria to produce novel secondary metabolites. In the current study, we highlight the disparities that exist between cultivation-independent and -dependent analyses of actinomycete communities from four locations in Lake Michigan sediment. Furthermore, through phylogenetic analysis of strains isolated from these locations, we identified a Streptomyces sp., strain B025, as being distinct from other Streptomyces spp. isolated from sediment. Upon fermentation this strain produced a rare class of eight-membered lactone secondary metabolites, which have been for their antitumor properties. We used spectroscopic and chemical derivitization techniques to characterize octalactin B (1) in addition to its corresponding novel, unnatural degradation product (2).