Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
권호 표지
DOI QR코드

DOI QR Code

Breast Lipofilling: A Review of Current Practice

  • Kasem, Abdul (The London Breast Institute, Princess Grace Hospital) ;
  • Wazir, Umar (The London Breast Institute, Princess Grace Hospital) ;
  • Headon, Hannah (The London Breast Institute, Princess Grace Hospital) ;
  • Mokbel, Kefah (The London Breast Institute, Princess Grace Hospital)
  • Received : 2014.08.10
  • Accepted : 2014.11.03
  • Published : 2015.03.15
Download PDF
⟨ Previous Next ⟩

Abstract

Lipofilling is a reconstructive and aesthetic technique that has recently grown in popularity and is increasingly being used in breast surgery. Previous concerns had been raised regarding its safety when used for remodelling and reconstruction of the breast; however, these concerns have since been dismissed. Over the subsequent two decades, little evidence has been found to support these early theoretical concerns, and growing numbers of proponents of the procedure are confident in its safety. Many developments and refinements in the technique have taken place in recent years, and several studies have been published regarding the safety of lipofilling in the breast. We reviewed the current literature regarding the use of different lipofilling techniques as well as the current evidence regarding the oncological safety of the procedure in patients seeking aesthetic breast enhancement and in patients requiring reconstruction after treatment for breast cancer.

Keywords

References

  1. Czerny V. Plastischer ersatz der brustdruse durch ein lipom. Verhandl Deutsche Ges Chir 1895;24:216-7.
  2. Coleman SR, Saboeiro AP. Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg 2007;119:775-85. https://doi.org/10.1097/01.prs.0000252001.59162.c9
  3. Lexer E. Freie fettransplantation. Dtsch Med Wochenschr 1910;36:340.
  4. Peer LA. Loss of volume in human fat grafts. Plast Reconstr Surg 1950;5:217. https://doi.org/10.1097/00006534-195003000-00002
  5. Bircoll M. Cosmetic breast augmentation utilizing autologous fat and liposuction techniques. Plast Reconstr Surg 1987;79:267-71. https://doi.org/10.1097/00006534-198702000-00022
  6. Report on autologous fat transplantation. ASPRS Ad-Hoc Committee on New Procedures, September 30, 1987. Plast Surg Nurs 1987;7:140-1. https://doi.org/10.1097/00006527-198700740-00027
  7. Brown FE, Sargent SK, Cohen SR, et al. Mammographic changes following reduction mammaplasty. Plast Reconstr Surg 1987;80:691-8. https://doi.org/10.1097/00006534-198711000-00006
  8. Isaacs G, Rozner L, Tudball C. Breast lumps after reduction mammaplasty. Ann Plast Surg 1985;15:394-9. https://doi.org/10.1097/00000637-198511000-00005
  9. Danikas D, Theodorou SJ, Kokkalis G, et al. Mammographic findings following reduction mammoplasty. Aesthetic Plast Surg 2001;25:283-5. https://doi.org/10.1007/s002660010137
  10. Largo RD, Tchang LA, Mele V, et al. Efficacy, safety and complications of autologous fat grafting to healthy breast tissue: a systematic review. J Plast Reconstr Aesthet Surg 2014;67:437-48. https://doi.org/10.1016/j.bjps.2013.11.011
  11. American Society of Plastic Surgeons. Fat transfer/fat graft and fat injection: ASPS guiding principles [Internet]. Arlington Heights, IL: American Society of Plastic Surgeons; 2009 [cited 2014 Dec 24]. Available from: http://www.plasticsurgery.org/Documents/medical-professionals/health-policy/guiding-principles/ASPS-Fat-Transfer-Graft-Guiding-Principles.pdf.
  12. Klein JA. Tumescent technique for local anesthesia improves safety in large-volume liposuction. Plast Reconstr Surg 1993;92:1085-98. https://doi.org/10.1097/00006534-199311000-00014
  13. Lee JH, Kirkham JC, McCormack MC, et al. The effect of pressure and shear on autologous fat grafting. Plast Reconstr Surg 2013;131:1125-36. https://doi.org/10.1097/PRS.0b013e3182879f4a
  14. Erdim M, Tezel E, Numanoglu A, et al. The effects of the size of liposuction cannula on adipocyte survival and the optimum temperature for fat graft storage: an experimental study. J Plast Reconstr Aesthet Surg 2009;62:1210-4. https://doi.org/10.1016/j.bjps.2008.03.016
  15. Kirkham JC, Lee JH, Medina MA 3rd, et al. The impact of liposuction cannula size on adipocyte viability. Ann Plast Surg 2012;69:479-81. https://doi.org/10.1097/SAP.0b013e31824a459f
  16. Agostini T, Lazzeri D, Pini A, et al. Wet and dry techniques for structural fat graft harvesting: histomorphometric and cell viability assessments of lipoaspirated samples. Plast Reconstr Surg 2012;130:331e-339e. https://doi.org/10.1097/PRS.0b013e3182589f76
  17. Ueberreiter K, von Finckenstein JG, Cromme F, et al. BEAULI: a new and easy method for large-volume fat grafts. Handchir Mikrochir Plast Chir 2010;42:379-85. https://doi.org/10.1055/s-0030-1267913
  18. Smith P, Adams WP Jr, Lipschitz AH, et al. Autologous human fat grafting: effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg 2006;117:1836-44. https://doi.org/10.1097/01.prs.0000218825.77014.78
  19. Chung CW, Marra KG, Li H, et al. VEGF microsphere technology to enhance vascularization in fat grafting. Ann Plast Surg 2012;69:213-9. https://doi.org/10.1097/SAP.0b013e3182573827
  20. Witort EJ, Pattarino J, Papucci L, et al. Autologous lipofilling: coenzyme Q10 can rescue adipocytes from stress-induced apoptotic death. Plast Reconstr Surg 2007;119:1191-9. https://doi.org/10.1097/01.prs.0000258395.81926.d8
  21. Coleman SR. Hand rejuvenation with structural fat grafting. Plast Reconstr Surg 2002;110:1731-44. https://doi.org/10.1097/00006534-200212000-00017
  22. Munch DP. Breast augmentation with autologous fat: experience of 96 procedures with the BEAULI-technique. Handchir Mikrochir Plast Chir 2013;45:80-92. https://doi.org/10.1055/s-0033-1343396
  23. Li FC, Chen B, Cheng L. Breast augmentation with autologous fat injection: a report of 105 cases. Ann Plast Surg 2014;73 Suppl 1:S37-4. https://doi.org/10.1097/SAP.0000000000000271
  24. Ferraro GA, De Francesco F, Tirino V, et al. Effects of a new centrifugation method on adipose cell viability for autologous fat grafting. Aesthetic Plast Surg 2011;35:341-8. https://doi.org/10.1007/s00266-010-9613-8
  25. Pulsfort AK, Wolter TP, Pallua N. The effect of centrifugal forces on viability of adipocytes in centrifuged lipoaspirates. Ann Plast Surg 2011;66:292-5. https://doi.org/10.1097/SAP.0b013e3181c7140e
  26. Kim IH, Yang JD, Lee DG, et al. Evaluation of centrifugation technique and effect of epinephrine on fat cell viability in autologous fat injection. Aesthet Surg J 2009;29:35-9. https://doi.org/10.1016/j.asj.2008.09.004
  27. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: a quantitative analysis of the role of centrifugation and harvest site. Plast Reconstr Surg 2004;113:391-5. https://doi.org/10.1097/01.PRS.0000097293.56504.00
  28. Conde-Green A, Wu I, Graham I, et al. Comparison of 3 techniques of fat grafting and cell-supplemented lipotransfer in athymic rats: a pilot study. Aesthet Surg J 2013;33:713-21. https://doi.org/10.1177/1090820X13487371
  29. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-95. https://doi.org/10.1091/mbc.E02-02-0105
  30. Khater R, Atanassova P, Anastassov Y, et al. Clinical and experimental study of autologous fat grafting after processing by centrifugation and serum lavage. Aesthetic Plast Surg 2009;33:37-43. https://doi.org/10.1007/s00266-008-9269-9
  31. Pfaff M, Wu W, Zellner E, et al. Processing technique for lipofilling influences adipose-derived stem cell concentration and cell viability in lipoaspirate. Aesthetic Plast Surg 2014;38:224-9. https://doi.org/10.1007/s00266-013-0261-7
  32. Matsumoto D, Sato K, Gonda K, et al. Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng 2006;12:3375-82. https://doi.org/10.1089/ten.2006.12.3375
  33. Kolle SF, Fischer-Nielsen A, Mathiasen AB, et al. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Lancet 2013;382:1113-20. https://doi.org/10.1016/S0140-6736(13)61410-5
  34. Peltoniemi HH, Salmi A, Miettinen S, et al. Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: a prospective comparative study. J Plast Reconstr Aesthet Surg 2013;66:1494-503. https://doi.org/10.1016/j.bjps.2013.06.002
  35. Khouri RK, Khouri RK Jr, Rigotti G, et al. Aesthetic applications of Brava-assisted megavolume fat grafting to the breasts: a 9-year, 476-patient, multicenter experience. Plast Reconstr Surg 2014;133:796-807. https://doi.org/10.1097/PRS.0000000000000053
  36. Khouri RK, Eisenmann-Klein M, Cardoso E, et al. Brava and autologous fat transfer is a safe and effective breast augmentation alternative: results of a 6-year, 81-patient, prospective multicenter study. Plast Reconstr Surg 2012;129:1173-87. https://doi.org/10.1097/PRS.0b013e31824a2db6
  37. Ho Quoc C, Delay E. Tolerance of pre-expansion BRAVA and fat grafting into the breast. Ann Chir Plast Esthet 2013;58:216-21. https://doi.org/10.1016/j.anplas.2012.10.016
  38. Rubin JP, Coon D, Zuley M, et al. Mammographic changes after fat transfer to the breast compared with changes after breast reduction: a blinded study. Plast Reconstr Surg 2012;129:1029-38. https://doi.org/10.1097/PRS.0b013e31824a2a8e
  39. Lohsiriwat V, Curigliano G, Rietjens M, et al. Autologous fat transplantation in patients with breast cancer: "silencing" or "fueling" cancer recurrence? Breast 2011;20:351-7. https://doi.org/10.1016/j.breast.2011.01.003
  40. Zocchi ML, Zuliani F. Bicompartmental breast lipostructuring. Aesthetic Plast Surg 2008;32:313-28. https://doi.org/10.1007/s00266-007-9089-3
  41. Perez-Cano R, Vranckx JJ, Lasso JM, et al. Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial. Eur J Surg Oncol 2012;38:382-9. https://doi.org/10.1016/j.ejso.2012.02.178
  42. Semprini G, Cattin F, Zanin C, et al. About locoregional recurrence risk after lipofilling in breast cancer patients: our experience. Minerva Chir 2014;69:91-6.
  43. Petit JY, Botteri E, Lohsiriwat V, et al. Locoregional recurrence risk after lipofilling in breast cancer patients. Ann Oncol 2012;23:582-8. https://doi.org/10.1093/annonc/mdr158
  44. Petit JY, Rietjens M, Botteri E, et al. Evaluation of fat grafting safety in patients with intraepithelial neoplasia: a matched-cohort study. Ann Oncol 2013;24:1479-84. https://doi.org/10.1093/annonc/mds660
  45. Sarfati I, Ihrai T, Duvernay A, et al. Autologous fat grafting to the postmastectomy irradiated chest wall prior to breast implant reconstruction: a series of 68 patients. Ann Chir Plast Esthet 2013;58:35-40. https://doi.org/10.1016/j.anplas.2012.10.007
  46. Iannace C, Di Libero L, Manetta F, et al. Coleman lipofilling: experience of an Italian group and review of the literature. Chir Ital 2009;61:67-75.
  47. Panettiere P, Marchetti L, Accorsi D. The serial free fat transfer in irradiated prosthetic breast reconstructions. Aesthetic Plast Surg 2009;33:695-700. https://doi.org/10.1007/s00266-009-9366-4

Cited by

  1. Autologous fat transplantation for breast reconstruction: A literature review vol.12, pp.None, 2015, https://doi.org/10.1016/j.amsu.2016.11.012
  2. The Effect of Lipoaspirates on Human Keratinocytes vol.36, pp.8, 2015, https://doi.org/10.1093/asj/sjw049
  3. Evolving Trends in Breast Surgery: Oncoplastic to Onco-Aesthetic Surgery vol.43, pp.2, 2015, https://doi.org/10.5999/aps.2016.43.2.222
  4. LIPOFILLING OPPORTUNITIES IN BREAST CANCER SURGERY vol.2016, pp.4, 2015, https://doi.org/10.21303/2504-5679.2016.00120
  5. Is explantation of silicone breast implants useful in patients with complaints? vol.65, pp.1, 2015, https://doi.org/10.1007/s12026-016-8813-y
  6. Breast Augmentation and Reconstruction from a Regenerative Medicine Point of View: State of the Art and Future Perspectives vol.23, pp.3, 2015, https://doi.org/10.1089/ten.teb.2016.0303
  7. Procedure, applications, and outcomes of autologous fat grafting vol.20, pp.None, 2015, https://doi.org/10.1016/j.amsu.2017.06.059
  8. Rhinoplasty with Fillers and Fat Grafting vol.33, pp.1, 2015, https://doi.org/10.1016/j.coms.2020.09.004
  9. Characterization of collagen type I/tannic acid beads as a cell scaffold vol.36, pp.2, 2015, https://doi.org/10.1177/0883911520988306
  10. Oncologic Safety of Autologous Fat Grafting in Breast Reconstruction vol.21, pp.4, 2015, https://doi.org/10.1016/j.clbc.2021.01.020