약학회지 (YAKHAK HOEJI)

  • 제59권1호
  • /
  • Pages.12-16
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  • 2015
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  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
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고리형 알콕시기를 함유한 크리신 유도체의 합성 및 일산화질소 생성 억제작용

Synthesis of 8-Cycloalkoxychrysin Analogs and their Inhibitory Activity Against NO Production

  • Kim, Sung-Soo (School of Medicine, Kangwon National University) ;
  • Park, Haeil (College of Pharmacy, Kangwon National University)
  • 투고 : 2015.01.23
  • 심사 : 2015.02.13
  • 발행 : 2015.02.28
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초록

Several 8-cycloalkoxychrysin analogs were synthesized from 6-benzyloxy-5,8-dihydroxyflavone and cycloalkanols in 2 steps and we evaluated their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. Among tested analogs, two analogs with cyclopentyl substructure (796 and 798) showed strong inhibitory activity against NO production.

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참고문헌

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