약학회지 (YAKHAK HOEJI)

  • 제59권1호
  • /
  • Pages.17-22
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  • 2015
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  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
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Acacetin의 HeLa 세포 Apoptosis 유도 효과

Effect of Acacetin on the Apoptosis Induction of HeLa Cells

  • 한수정 (숙명여자대학교 약학대학) ;
  • 김안근 (숙명여자대학교 약학대학)
  • Han, Su Jung (College of Pharmacy, Sookmyung Women's University) ;
  • Kim, An Keun (College of Pharmacy, Sookmyung Women's University)
  • 투고 : 2015.02.03
  • 심사 : 2015.02.16
  • 발행 : 2015.02.28
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초록

In this study, we examined the effect of acacetin on the apoptosis induction of HeLa human cervical cancer cells. The results showed that acacetin inhibited the cell viability and induced apoptosis, leading to PARP cleavage and activation of caspase-9, -3, and -7. Moreover, acacetin-induced apoptosis was attenuated by a broad caspase inhibitor, z-VAD-fmk. Also, acacetin resulted in a loss of mitochondria membrane potential. Taken together, our results demonstrate that the induction of apoptosis by acacetin in HeLa cells is associated with caspase activation via the mitochondria pathway.

키워드

참고문헌

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피인용 문헌

  1. Pharmacologic Inhibition of Autophagy Sensitizes Human Acute Leukemia Jurkat T Cells to Acacetin-Induced Apoptosis vol.27, pp.1, 2015, https://doi.org/10.4014/jmb.1610.10055
  2. Flavonoids over women’s health: a literature review vol.19, pp.2, 2018, https://doi.org/10.12729/jbtr.2018.19.2.032