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http://dx.doi.org/10.17480/psk.2015.59.1.12

Synthesis of 8-Cycloalkoxychrysin Analogs and their Inhibitory Activity Against NO Production  

Kim, Sung-Soo (School of Medicine, Kangwon National University)
Park, Haeil (College of Pharmacy, Kangwon National University)
Publication Information
YAKHAK HOEJI / v.59, no.1, 2015 , pp. 12-16 More about this Journal
Abstract
Several 8-cycloalkoxychrysin analogs were synthesized from 6-benzyloxy-5,8-dihydroxyflavone and cycloalkanols in 2 steps and we evaluated their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. Among tested analogs, two analogs with cyclopentyl substructure (796 and 798) showed strong inhibitory activity against NO production.
Keywords
chrysin; 8-cycloalkoxychrysin; anti-inflammatory; nitric oxide (NO);
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Times Cited By KSCI : 5  (Citation Analysis)
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