Restorative Dentistry and Endodontics

  • 제40권1호
  • /
  • Pages.14-22
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  • 2015
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  • 2234-7658(pISSN)
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  • 2234-7666(eISSN)
대한치과보존학회 (The Korean Academy of Conservative Dentistry)
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Epigenetics: general characteristics and implications for oral health

  • Seo, Ji-Yun (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute) ;
  • Park, Yoon-Jung (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Yi, Young-Ah (Department of Dentistry, Inje University Seoul Paik Hospital) ;
  • Hwang, Ji-Yun (Nutrition Education Major, Graduate School of Education, Sangmyung University) ;
  • Lee, In-Bog (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute) ;
  • Cho, Byeong-Hoon (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute) ;
  • Son, Ho-Hyun (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute) ;
  • Seo, Deog-Gyu (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute)
  • 투고 : 2014.04.11
  • 심사 : 2014.09.11
  • 발행 : 2015.02.28
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초록

Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.

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