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http://dx.doi.org/10.5395/rde.2015.40.1.14

Epigenetics: general characteristics and implications for oral health  

Seo, Ji-Yun (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute)
Park, Yoon-Jung (Department of Nutritional Science and Food Management, Ewha Womans University)
Yi, Young-Ah (Department of Dentistry, Inje University Seoul Paik Hospital)
Hwang, Ji-Yun (Nutrition Education Major, Graduate School of Education, Sangmyung University)
Lee, In-Bog (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute)
Cho, Byeong-Hoon (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute)
Son, Ho-Hyun (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute)
Seo, Deog-Gyu (Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute)
Publication Information
Restorative Dentistry and Endodontics / v.40, no.1, 2015 , pp. 14-22 More about this Journal
Abstract
Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.
Keywords
Dental pulp cell; Epigenetic mechanism; Epigenetics; Gene regulation; Periodontitis;
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