Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Immunohistochemical Expression of Cytokeratins and Epithelial Membrane Protein 2 in Nasopharyngeal Carcinoma and its Potential Implications

  • Ahmed, Hussain Gadelkarim (Department of Pathology, College of Medicine, University of Hail) ;
  • Suliman, Rania Saad Abdul Gader (Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University for Science and Technology) ;
  • Abd El Aziz, Mohammed Siddig (Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University for Science and Technology) ;
  • Alshammari, Fawaz D. (Department of Medical Laboratory Science, College of Applied Medical Science, University of Hail)
  • Published : 2015.02.25
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Abstract

Background: Nasopharyngeal carcinoma (NPC) is an aggressive disease and tends to involve surrounding tissues, and biomarkers for better management are yet to be identified. Materials and Methods: One hundred and fifty tissue samples with NPC diagnosis were were investigated using pan cytokeratin (CK) and epithelial membrane protein 2 (EMP2) antibodies. Results: Immunohistochemical expression of CK was identified in 144/150 (96%) and of EMP2 in 120/150 (80%). Conclusions: There is a high loss of EMP2 in NPC, especially high grade examples. Loss of CK expression is also linked to high grade NPC types.

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References

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