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http://dx.doi.org/10.7314/APJCP.2015.16.2.653

Immunohistochemical Expression of Cytokeratins and Epithelial Membrane Protein 2 in Nasopharyngeal Carcinoma and its Potential Implications  

Ahmed, Hussain Gadelkarim (Department of Pathology, College of Medicine, University of Hail)
Suliman, Rania Saad Abdul Gader (Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University for Science and Technology)
Abd El Aziz, Mohammed Siddig (Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University for Science and Technology)
Alshammari, Fawaz D. (Department of Medical Laboratory Science, College of Applied Medical Science, University of Hail)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.2, 2015 , pp. 653-656 More about this Journal
Abstract
Background: Nasopharyngeal carcinoma (NPC) is an aggressive disease and tends to involve surrounding tissues, and biomarkers for better management are yet to be identified. Materials and Methods: One hundred and fifty tissue samples with NPC diagnosis were were investigated using pan cytokeratin (CK) and epithelial membrane protein 2 (EMP2) antibodies. Results: Immunohistochemical expression of CK was identified in 144/150 (96%) and of EMP2 in 120/150 (80%). Conclusions: There is a high loss of EMP2 in NPC, especially high grade examples. Loss of CK expression is also linked to high grade NPC types.
Keywords
Nasopharyngeal carcinoma; cytokeratin; EMP2; immunohistochemistry;
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