YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Anticoccidial Effect of 3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108)

3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108) 화합물의 항콕시디움 효과

  • Yeo, Seon-Ju (Zoonosis Research Center, Department of Infection Biology, School of Medicine, Wonkwang University) ;
  • Kim, Hak Sung (College of Pharmacy, Wonkwang University) ;
  • Kim, Suk (College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Kee-In (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Park, Hyun (Zoonosis Research Center, Department of Infection Biology, School of Medicine, Wonkwang University)
  • Received : 2015.11.11
  • Accepted : 2015.11.19
  • Published : 2015.12.31
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Abstract

Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by $33{\pm}2.64%$ and $23{\pm}3.60%$ (P<0.001) at $7^{th}$ day and $9^{th}$ day p.i.. Conclusively, compound 5-108 was effective against T. gondii and E. tenella.

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References

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