Korean Journal of Air-Conditioning and Refrigeration Engineering (설비공학논문집)

The Society of Air-Conditioning and Refrigerating Engineers of Korea (대한설비공학회)
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An Experimental Study on the Freeze Drying Process for Poly γ Glutamic Acid

폴리감마글루탐산의 동결 건조 과정의 실험적 연구

  • Kang, Jisu (Department of Mechanical Engineering, Graduate School of Kookmin University) ;
  • Sim, Yeon-Ho (Department of Mechanical Engineering, Graduate School of Kookmin University) ;
  • Byun, Si-Ye (Department of Mechanical Engineering, Graduate School of Kookmin University) ;
  • Chang, Young Soo (School of Mechanical Systems Engineering, Kookmin University) ;
  • Kang, Byung Ha (School of Mechanical Systems Engineering, Kookmin University)
  • 강지수 (국민대학교 대학원 기계공학과) ;
  • 심연호 (국민대학교 대학원 기계공학과) ;
  • 변시예 (국민대학교 대학원 기계공학과) ;
  • 장영수 (국민대학교 기계공학시스템공학부) ;
  • 강병하 (국민대학교 기계공학시스템공학부)
  • Received : 2015.04.28
  • Accepted : 2015.10.30
  • Published : 2015.12.10
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Abstract

This paper presents an experimental study on the freeze drying process for poly ${\gamma}$ glutamic acid. The physical properties of poly ${\gamma}$ glutamic acid are measured during the freeze-drying process. The moisture contents of poly ${\gamma}$ glutamic acid according to the glass transient temperature are obtained by DSC (Differential Scanning Calorimetry) analysis. The end point of primary drying for the poly ${\gamma}$ glutamic acid with a thickness of 3 mm is obtained by measuring the thickness of the dried layer, the amount of moisture evaporation, the moisture content, and the pressure in the drying vacuum chamber during the freeze-drying process. By considering the variation in the glass transient temperature with respect to the moisture content of the material, a control schedule for the heating plate temperature is suggested during the secondary drying process.

Keywords

References

  1. Franks, F., 1998, Freeze-drying of bioproducts:putting principles into practice, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 45, No. 3, pp. 221-229. https://doi.org/10.1016/S0939-6411(98)00004-6
  2. Adams, G. D. J., Cook, I., and Ward, K. R., 2014, The Principles of Freeze-Drying, Methods in Molecular Biology, Vol. 1257, pp. 121-143.
  3. Kang, J. Y., 2004, Automatic control of pharmaceutical vacuum freeze dryer, Dongguk Graduate school.
  4. Park, S. J. and Song, C. S., 2003, Vacuum freezing dryer, Korean Journal of Air-Conditioning and Refrigeration Engineering, pp. 29-40.
  5. Sung, M. H. and Park, C., 2009, New bioindustrial development of high molecular weight of poly-gamma-glutamic acid produced by Bacillus subtilis(chungkookjang), Polymer Science and Technology, Vol. 20, No. 5, pp. 440-446.
  6. Jung, G. H., Moon, S. H., Choi, J. H., Lee, J. W., and Kim, N. I., 2011, Poly-${\gamma}$-glutamic acid modifies cytokine release in vitro, J Kyung Hee Univ Med cent, Vol. 27, No. 1, pp. 34-42.
  7. Ogunleye, A., Bhat, A., Irorere, V. U., Hill, D., Williams, C., and Radecka, I., Poly-${\gamma}$-glutamic acid production, properties and applications, Faculty of Science and Engineering, University of Wolverhampton, Wulfuruna street, Wolverhampton, UK.
  8. Park, H. Y., 1990, Freezing dryer, The magazine of the Korea refrigerating and air conditioning technology association, Vol. 7, No. 9, pp. 42-57.
  9. Park, N. H., Kim, B. S., Kang, T. S., and Shin, D. H., 1998, Modification of conventional freeze dryer, Korean J. Food SCI. Technol, Vol. 20, No. 3, pp. 350-356.
  10. Roy, M. L. and Pikal, M. J., 1989, Process control in freeze drying:determination of the end point of sublimation drying by an electronic moisture sensor, Pharmaceutical Science and Technology, Vol. 43, No. 2, pp. 60-66.
  11. Bhandrari, B. R. and Howes, T., 1999, Implication of glass transition for the drying and stability of dried foods, Journal of Food Engineering, Vol 40, pp. 71-79. https://doi.org/10.1016/S0260-8774(99)00039-4
  12. Lee, S. J., 2004, Considertion for the optimum operation of vacuum freeze drying, Food Engineering Progress, Vol. 8, No. 3, pp. 147-157.
  13. Tang, X. and Pikal, M. J., 2004, Design of freeze drying process for pharmaceuticals:practical advice, Pharmaceutical research, Vol. 21, No. 2, pp. 191-200. https://doi.org/10.1023/B:PHAM.0000016234.73023.75
  14. Pikal, M. J., Shah, S., Roy, M. L., and Putman, R., 1990, International Journal of Pharmaceutics, The secondary drying stage of freeze drying:drying kinetics as a function of temperature and chamber preesure, Vol. 60, No. 3, pp. 203-207. https://doi.org/10.1016/0378-5173(90)90074-E
  15. Zhai, S., Taylor, R., Sanches, R., and Slater, N. K. H., 2003, Measurement of lyophilisation primary drying by freeze-drying microscopy, Chemical Engineering Science, Vol. 58, pp. 2313-2323. https://doi.org/10.1016/S0009-2509(03)00090-3

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