Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A New Flavonol Glycoside from the Leaves of Boscia senegalensis

  • Morgan, Abubaker M.A. (College of Pharmacy, Chungnam National University) ;
  • Kim, Jang Hoon (College of Pharmacy, Chungnam National University) ;
  • Kim, Sang Kyum (College of Pharmacy, Chungnam National University) ;
  • Lim, Chi-Hwan (College of Agriculture and Life Sciences, Chungnam National University) ;
  • Kim, Young Ho (College of Pharmacy, Chungnam National University)
  • Received : 2014.06.30
  • Accepted : 2014.08.06
  • Published : 2014.12.20
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Abstract

Detailed chemical investigation of Boscia senegalensis (Per) Lam. ex Poir. led to the isolation of one new flavonol glycoside, rhamnocitrin-3-O-${\beta}$-$\small{D}$-(6"-O-E-feruloyl)-glucopyranoside named bosenegaloside A (1), with seven known compounds, rhamnocitrin-3-O-${\beta}$-$\small{D}$-(6"-O-E-p-coumaroyl)-glucopyranoside (2), rhamnocitrin-3-O-${\beta}$-$\small{D}$-glucopyranoside (3), 3,4,5-trimethoxyphenol-${\beta}$-$\small{D}$-glucopyrinoside (4), lasianthionoside A (5), 3,7-dimethyl-1-octene-3,6,7-triol-6-O-${\beta}$-$\small{D}$-glucopyranoside (6), syringin (7), and austroside B (8). The chemical structures of these compounds were elucidated from spectroscopic data and by comparison of these data with previously published results. The inhibitory activity of the isolated compounds on soluble epoxide hydrolase (sEH) was assessed. Compounds 1-3 potently inhibited sEH activity with $IC_{50}$ values of $12.8{\pm}0.5$, $18.4{\pm}0.2$, and $11.3{\pm}0.9{\mu}M$, respectively.

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