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http://dx.doi.org/10.5012/bkcs.2014.35.12.3447

A New Flavonol Glycoside from the Leaves of Boscia senegalensis  

Morgan, Abubaker M.A. (College of Pharmacy, Chungnam National University)
Kim, Jang Hoon (College of Pharmacy, Chungnam National University)
Kim, Sang Kyum (College of Pharmacy, Chungnam National University)
Lim, Chi-Hwan (College of Agriculture and Life Sciences, Chungnam National University)
Kim, Young Ho (College of Pharmacy, Chungnam National University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.12, 2014 , pp. 3447-3452 More about this Journal
Abstract
Detailed chemical investigation of Boscia senegalensis (Per) Lam. ex Poir. led to the isolation of one new flavonol glycoside, rhamnocitrin-3-O-${\beta}$-$\small{D}$-(6"-O-E-feruloyl)-glucopyranoside named bosenegaloside A (1), with seven known compounds, rhamnocitrin-3-O-${\beta}$-$\small{D}$-(6"-O-E-p-coumaroyl)-glucopyranoside (2), rhamnocitrin-3-O-${\beta}$-$\small{D}$-glucopyranoside (3), 3,4,5-trimethoxyphenol-${\beta}$-$\small{D}$-glucopyrinoside (4), lasianthionoside A (5), 3,7-dimethyl-1-octene-3,6,7-triol-6-O-${\beta}$-$\small{D}$-glucopyranoside (6), syringin (7), and austroside B (8). The chemical structures of these compounds were elucidated from spectroscopic data and by comparison of these data with previously published results. The inhibitory activity of the isolated compounds on soluble epoxide hydrolase (sEH) was assessed. Compounds 1-3 potently inhibited sEH activity with $IC_{50}$ values of $12.8{\pm}0.5$, $18.4{\pm}0.2$, and $11.3{\pm}0.9{\mu}M$, respectively.
Keywords
Boscia senegalensis; Capparaceae; Flavonol glycoside; Soluble epoxide hydrolase;
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