Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Carbazole Based Bimodal "Turn-On" Fluorescent Probe for Biothiols (Cysteine/Homocysteine) and Fluoride: Sensing, Imaging and its Applications

  • Kaur, Matinder (Department of Chemistry, Research Institute for Natural Sciences, Korea University) ;
  • Yoon, Byungkwon (Department of Chemistry, Research Institute for Natural Sciences, Korea University) ;
  • Kumar, Rajesh (Department of Chemistry, Research Institute for Natural Sciences, Korea University) ;
  • Cho, Min Ju (Department of Chemistry, Research Institute for Natural Sciences, Korea University) ;
  • Kim, Hak Joong (Department of Chemistry, Research Institute for Natural Sciences, Korea University) ;
  • Kim, Jong Seung (Department of Chemistry, Research Institute for Natural Sciences, Korea University) ;
  • Choi, Dong Hoon (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
  • Received : 2014.06.17
  • Accepted : 2014.08.06
  • Published : 2014.12.20
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Abstract

A well-known carbazole-based precursor (probe 1) was used for the detection of cysteine/homocysteine and fluoride. Probe 1 shows a "turn-on" response to cysteine/homocysteine and fluoride via enhancement in emission intensity at 442 nm and 462 nm respectively, in solutions and living cells. Furthermore, probe 1 behaves as a fluorescent molecular switch between cysteine/homocysteine and fluoride as the chemical inputs, which have been used for the development of a combinatorial logic circuit and a molecular keypad lock.

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References

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