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http://dx.doi.org/10.5012/bkcs.2014.35.12.3437

A Carbazole Based Bimodal "Turn-On" Fluorescent Probe for Biothiols (Cysteine/Homocysteine) and Fluoride: Sensing, Imaging and its Applications  

Kaur, Matinder (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
Yoon, Byungkwon (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
Kumar, Rajesh (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
Cho, Min Ju (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
Kim, Hak Joong (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
Kim, Jong Seung (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
Choi, Dong Hoon (Department of Chemistry, Research Institute for Natural Sciences, Korea University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.12, 2014 , pp. 3437-3442 More about this Journal
Abstract
A well-known carbazole-based precursor (probe 1) was used for the detection of cysteine/homocysteine and fluoride. Probe 1 shows a "turn-on" response to cysteine/homocysteine and fluoride via enhancement in emission intensity at 442 nm and 462 nm respectively, in solutions and living cells. Furthermore, probe 1 behaves as a fluorescent molecular switch between cysteine/homocysteine and fluoride as the chemical inputs, which have been used for the development of a combinatorial logic circuit and a molecular keypad lock.
Keywords
Carbazole probe; Cysteine/homocysteine sensing; Fluoride recognition; Molecular keypad lock; Bioimaging;
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