Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis

  • Wang, Chao (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Ma, Hong-Xi (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Jin, Mei-Shan (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Zou, Ya-Bin (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Teng, Yong-Liang (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Tian, Zhuang (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Wang, Hai-Ying (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Wang, Yin-Ping (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) ;
  • Duan, Xiu-Mei (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
  • Published : 2014.05.30
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Abstract

Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performed to assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelial cell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was no statistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumor size, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9 levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cell morphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteins increased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9 expression with advanced EGIST behavior.

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References

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