Asian Pacific Journal of Cancer Prevention

  • 제15권13호
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  • Pages.5175-5180
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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MicroRNAs as Promising Biomarkers for Tumor-staging: Evaluation of MiR21 MiR155 MiR29a and MiR92a in Predicting Tumor Stage of Rectal Cancer

  • Yang, Yun (Department of Gastrointestinal Surgery, West China Hospital) ;
  • Peng, Wei (West China Medical School, Department of Hepatic Surgery and Hepatic Transplantation Center, West China Hospital) ;
  • Tang, Tian (West China Medical School, Department of Gynecology and Obstetrics, West China Women's and Children's Hospital) ;
  • Xia, Lin (Department of Gastrointestinal Surgery, West China Hospital) ;
  • Wang, Xiao-Dong (Department of Gastrointestinal Surgery, West China Hospital) ;
  • Duan, Bao-Feng (Department of Oncology, West China Hospital, Sichuan University) ;
  • Shu, Ye (Department of Gastrointestinal Surgery, West China Hospital)
  • 발행 : 2014.07.15
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초록

Objective: In this study, tumor-stage predictive abilities of miR21, miR155, miR29a and miR92a were evaluated in rectal cancer (RC). Methods: Expression of miR21, miR155, miR29a and miR92a was detected and quantitated in tumor tissue and in adjacent normal tissue from 40 patients by TaqMan MicroRNA assay. Results: Significant overexpression of miR21, miR155, miR29a and miR92a was observed in RC tissues. While high expression of miR21, miR155 and miR29a in N1-2 and C-D stages presented a potential correlation with N and Duke stages, partial correlation analysis suggested that only miR155 rather than miR21 and miR29a played a greater influencing role. Receiver operating characteristics (ROC) curve analysis showed that miR155 could discriminate N0 from N1-2 with 85.0% sensitivity and 85.0% specificity, N2 from N0-1 with 90.0% sensitivity and 96.7% specificity, and C-D stage from A-B stage with 81.0% sensitivity and 84.2% specificity. Conclusions: Increase in expression of miR155 might represent a novel predictor for RC N and Dukes staging.

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참고문헌

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피인용 문헌

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  2. MicroRNA Expression Profiling to Identify and Validate Reference Genes for the Relative Quantification of microRNA in Rectal Cancer vol.11, pp.3, 2016, https://doi.org/10.1371/journal.pone.0150593
  3. MicroRNAs in colorectal carcinoma - from pathogenesis to therapy vol.35, pp.1, 2016, https://doi.org/10.1186/s13046-016-0320-4
  4. Clinical Diagnostic Implications of Body Fluid MiRNA in Oral Squamous Cell Carcinoma vol.94, pp.37, 2015, https://doi.org/10.1097/MD.0000000000001324