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  • 제14권1호
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  • Pages.14-20
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  • 2014
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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NF-${\kappa}B$ Activation in T Helper 17 Cell Differentiation

  • Park, Sang-Heon (School of Life Sciences, Gwangju Institute of Science and Technology (GIST)) ;
  • Cho, Gabi (School of Life Sciences, Gwangju Institute of Science and Technology (GIST)) ;
  • Park, Sung-Gyoo (School of Life Sciences, Gwangju Institute of Science and Technology (GIST))
  • 투고 : 2013.11.29
  • 심사 : 2014.02.04
  • 발행 : 2014.02.28
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⟨ 이전 논문 다음 논문 ⟩

초록

CD28/T cell receptor ligation activates the NF-${\kappa}B$ signaling cascade during CD4 T cell activation. NF-${\kappa}B$ activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-${\kappa}B$ activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-${\kappa}B$ activation pathway and its effect on Th17 cell differentiation.

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참고문헌

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