한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제31권6호
  • /
  • Pages.535-538
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  • 2014
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

비글견에서 신장 아밀로이드증 증례

Renal Amyloidosis in a Beagle

  • Jung, Joohyun (Ilsan animal medical center) ;
  • Jin, Jaebong (Ilsan animal medical center) ;
  • Lee, Hyunuk (Ilsan animal medical center) ;
  • Choi, Mincheol (Veterinary Radiology Department, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
  • 심사 : 2014.12.16
  • 발행 : 2014.12.31
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초록

8년령의 수컷 비글견이 이틀 동안 식욕 부진, 구토, 기력 저하를 주증으로 내원하였다. 혈액학적 검사에서 경등도의 질소혈증과 심각한 저알부민혈증, 뇨 검사에서 심각한 단백뇨가 관찰되었다. 복부 초음파 검사에서 양쪽 신장의 크기가 증가하고 미만성 고에코의 피질이 두드러지게 관찰되었다. 신장 생검과 조직 검사 결과 신장 아밀로이드증으로 확진되었다. 3 개월 동안 환자는 적극적인 내과적 관리를 받았고, 보호자는 환자의 삶의 질에 만족하였다. 이후 심각한 질소혈증과 콩팥증후군이 발생하여 안락사가 실시되었다.

An eight-year-old intact male Beagle had anorexia, vomiting, depression for two days. The dog had hypoalbuminenia and mild azotemia on hematologic and clinical chemistry examinations. Severe proteinuria was identified on urinalysis. On abdominal ultrasonographs, there were small amount of ascites and bilateral renomegaly with severe hyperechoic renal cortex and hyperechoic medullary rim sign. Renal biopsy and histopathology revealed renal amyloidosis. The quality of life in this dog was satisfactory with aggressive supportive care for three months. Euthanasia was performed due to deteriorated azotemia and nephrotic syndrome.

키워드

참고문헌

  1. Benson MD, Dwulet FE, DiBartola SP. Identification and characterization of amyloid protein AA in spontaneous canine amyloidosis. Lab Invest 1985; 52: 448-452.
  2. Bowles MH, Mosier DA. Renal amyloidosis in a family of beagles. J Am Vet Med Assoc 1992; 201: 569-574.
  3. Boyce JT, DiBartola SP, Chew DJ, Gasper PW. Familial renal amyloidosis in Abyssinian cats. Vet Pathol 1984; 21: 33-38. https://doi.org/10.1177/030098588402100106
  4. Cook AK, Cowgill LD. Clinical and pathological features of protein-losing glomerular disease in the dog: a review of 137 cases (1985-1992). J Am Anim Hosp Assoc 1996; 32: 313-322. https://doi.org/10.5326/15473317-32-4-313
  5. D'Anjou MA. Kidneys and ureters. In: Atlas of small animal ultrasonography, Wiley-Blackwell 2008; 342-346.
  6. DiBartola SP. The pathogenesis of reactive systemic amyloidosis. J Vet Intern Med 1989; 3: 31-41. https://doi.org/10.1111/j.1939-1676.1989.tb00326.x
  7. DiBartola SP, Benson MD, Dwulet FE, Cornacoff JB. Isolation and characterization of amyloid protein AA in the Abyssinian cat. Lab Invest 1985; 52: 485-489.
  8. DiBartola SP, Tarr MJ, Benson MD. Tissue distribution of amyloid deposits in Abyssinian cats with familial amyloidosis. J Comp Pathol 1986; 96: 387-398. https://doi.org/10.1016/0021-9975(86)90034-4
  9. DiBartola SP, Tarr MJ, Parker AT, Powers JD, Pultz JA. Clinicopathologic findings in dogs with renal amyloidosis: 59 cases (1976-1986). J Am Vet Med Assoc 1989; 195: 358-364.
  10. DiBartola SP, Tarr MJ, Webb DM, Giger U. Familial renal amyloidosis in Chinese Shar Pei dogs. J Am Vet Med Assoc 1990; 197: 483-487.
  11. Dubuis JC, Schmid V, Boujon P. Two cases of renal amyloidosis in the Shar pei. Schweiz Arch Tierheilkd 1998; 140: 156-160.
  12. Klosterman ES, Moore GE, de Brito Galvao JF, DiBartola SP, Groman RP, Whittemore JC, Vaden SL, Harris TL, Byron JK, Dowling SR, Grant DC, Grauer GF, Pressler BM. Comparison of signalment, clinicopathologic findings, histologic diagnosis, and prognosis in dogs with glomerular disease with or without nephrotic syndrome. J Vet Intern Med 2011; 25: 206-214. https://doi.org/10.1111/j.1939-1676.2010.0669.x
  13. Littman, Meryl P. Protein-losing nephropathy in small animals. Veterinary Clinics of North America: Small Animal Practice 41. 2011; 31-62. https://doi.org/10.1016/j.cvsm.2010.09.006
  14. Logan JC, Callan MB, Drew K, Marryott K, Oakley DA, Jefferies L, Giger U. Clinical indications for use of fresh frozen plasma in dogs: 74 dogs (October through December 1999). J Am Vet Med Assoc 2001; 218: 1449-1455. https://doi.org/10.2460/javma.2001.218.1449
  15. Mantis P, Lamb CR. Most dogs with medullary rim sign on ultrasonography have no demonstrable renal dysfunction. Vet Radiol Ultrasound 2000; 41: 164-166. https://doi.org/10.1111/j.1740-8261.2000.tb01471.x
  16. Mason NJ, Day MJ. Renal amyloidosis in related English foxhounds. J Small Anim Pract 1996; 37: 255-260. https://doi.org/10.1111/j.1748-5827.1996.tb02374.x
  17. Niewold TA, van der Linde-Sipman JS, Murphy C, Tooten PC, Gruys E. Familial amyloidosis in cats: Siamese and Abyssinian AA proteins differ in primary sequence and pattern of deposition. Amyloid 1999; 6: 205-209. https://doi.org/10.3109/13506129909007328
  18. Rivas AL, Tintle L, Meyers-Wallen V, Scarlett JM, van Tassell CP, Quimby FW. Inheritance of renal amyloidosis in Chinese Shar-pei dogs. J Hered 1993; 84: 438-442. https://doi.org/10.1093/oxfordjournals.jhered.a111369
  19. Schneider SM, Cianciolo RE, Nabity MB, Clubb FJ Jr, Brown CA, Lees GE. Prevalence of immune-complex glomerulonephritides in dogs biopsied for suspected glomerular disease: 501 cases (2007-2012). J Vet Intern Med 2013; 27 Suppl 1: S67-75. https://doi.org/10.1111/jvim.12247
  20. Segev G, Cowgill LD, Jessen S, Berkowitz A, Mohr CF, Aroch I. Renal amyloidosis in dogs: a retrospective study of 91 cases with comparison of the disease between Shar-Pei and non-Shar-Pei dogs. J Vet Intern Med 2012; 26: 59-68.
  21. Vaden SL. Glomerular diseases. In: Textbook of Veterinary Internal Medicine, 7th ed. St. Louis: Elsevier Saunders. 2005; 2030-2031.
  22. Vaden SL, Levine JF, Lees GE, Groman RP, Grauer GF, Forrester SD. Renal biopsy: a retrospective study of methods and complications in 283 dogs and 65 cats. J Vet Intern Med 2005; 19: 794-801. https://doi.org/10.1111/j.1939-1676.2005.tb02767.x
  23. Watson AD. The nephrotic syndrome due to renal amyloidosis in a dog. Aust Vet J 1971; 47: 398-401. https://doi.org/10.1111/j.1751-0813.1971.tb09224.x