IMMUNE NETWORK

  • 제14권6호
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  • Pages.277-288
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  • 2014
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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DOI QR코드

DOI QR Code

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

  • Kim, Chang H. (Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Veterinary Medicine, Weldon School of Biomedical Engineering, Center for Cancer Research, Purdue University) ;
  • Park, Jeongho (Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Veterinary Medicine, Weldon School of Biomedical Engineering, Center for Cancer Research, Purdue University) ;
  • Kim, Myunghoo (Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Veterinary Medicine, Weldon School of Biomedical Engineering, Center for Cancer Research, Purdue University)
  • 투고 : 2014.10.16
  • 심사 : 2014.11.28
  • 발행 : 2014.12.31
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초록

T cells are central players in the regulation of adaptive immunity and immune tolerance. In the periphery, T cell differentiation for maturation and effector function is regulated by a number of factors. Various factors such as antigens, co-stimulation signals, and cytokines regulate T cell differentiation into functionally specialized effector and regulatory T cells. Other factors such as nutrients, micronutrients, nuclear hormones and microbial products provide important environmental cues for T cell differentiation. A mounting body of evidence indicates that the microbial metabolites short-chain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation. We review the current status of our understanding of SCFA functions in regulation of peripheral T cell activity and discuss their impact on tissue inflammation.

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  110. The Role of the Gut Microbiome in Pathogenesis, Biology, and Treatment of Plasma Cell Dyscrasias vol.11, pp.None, 2014, https://doi.org/10.3389/fonc.2021.741376
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