대한산업공학회지 (Journal of Korean Institute of Industrial Engineers)

  • 제39권5호
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  • Pages.403-411
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  • 2013
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  • 1225-0988(pISSN)
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  • 2234-6457(eISSN)
대한산업공학회 (Korean Institute of Industrial Engineers)
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의약품개발공정에서의 Augmented weighted Tchebycheff 모델링 및 강건설계최적화

Augmented Weighted Tchebycheff Modeling and Robust Design Optimization on a Drug Development Process

  • ;
  • 신상문 (동아대학교 산업경영공학과)
  • Ho, Le Tuan (Department of Industrial and Management Systems Engineering, Dong-A University) ;
  • Shin, Sangmun (Department of Industrial and Management Systems Engineering, Dong-A University)
  • 투고 : 2013.07.31
  • 심사 : 2013.09.16
  • 발행 : 2013.10.15
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초록

The quality of the products/processes has been improved remarkably since robust design (RD) methodology is applied into the practice manufacturing processes. A model building method based on the dual responses methods for multiple and time oriented responses on a drug development process is employed in this paper instead of the previous methods that handle the static nature of data and single response. Subsequently, the optimal solutions of a multiple and time series RD problem are obtained by using the proposed augmented weighted Tchebycheff method that has a significant flexibility on assigning weights. Finally, a pharmaceutical case study associated with a generic drug development process is conducted in order to illustrate the efficient optimal solutions from the proposed model.

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참고문헌

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