Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Recent Insights in the Removal of Klebseilla Pathogenicity Factors for the Industrial Production of 2,3-Butanediol

  • Shrivastav, Anupama (Institute of Life Sciences and Resources, and Department of Food Science and Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Lee, Jinwon (Department of Chemical and Biomolecular Engineering, Sogang University) ;
  • Kim, Hae-Yeong (Institute of Life Sciences and Resources, and Department of Food Science and Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Kim, Young-Rok (Institute of Life Sciences and Resources, and Department of Food Science and Biotechnology, College of Life Sciences, Kyung Hee University)
  • Received : 2013.02.27
  • Accepted : 2013.03.18
  • Published : 2013.07.28
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Abstract

2,3-Butanediol (2,3-BDO) has immense industrial applications. Recently, microbial fermentation has emerged as an alternative way to produce this industrially important chemical. Although 2,3-BDO is produced by several microorganisms, the Klebsiella genera has an excellent production compared with other 2,3-BDO-producing microorganisms. In order to produce 2,3-BDO on a large scale, the challenges of removing pathogenic factors from Klebsiella pneumoniae need to be addressed. K. pneumoniae produces a number of virulence factors that contribute to its pathogenesis, including lipopolysaccharides, capsules, fimbrial adhesins, etc. Removal of these pathogenic factors from 2,3-BDO-producing Klebsiella strains will result in avirulent strains for the safe, economic, and efficient production of 2,3-BDO. In this review, we summarize the current trends in 2,3-BDO production using K. pneumoniae and insights into the removal of its virulence factors for industrial applications.

Keywords

References

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