Clean Technology (청정기술)

The Korean Society of Clean Technology (한국청정기술학회)
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Effect of Silica-Alumina Adsorbent on the Efficiency of Paclitaxel Purification

파클리탁셀 정제 효율에 미치는 실리카-알루미나 흡착제의 영향

  • Oh, Hyeon-Jeong (Department of Chemical Engineering, Kongju National University) ;
  • Jung, Kyeong Youl (Department of Chemical Engineering, Kongju National University) ;
  • Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
  • 오현정 (공주대학교 화학공학부) ;
  • 정경열 (공주대학교 화학공학부) ;
  • 김진현 (공주대학교 화학공학부)
  • Received : 2013.05.23
  • Accepted : 2013.06.12
  • Published : 2013.09.30
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Abstract

Several types of mesoporous silica-alumina adsorbents with varied $SiO_2/Al_2O_3$ ratios were prepared by spray pyrolysis and were used for the purification of the anticancer agent paclitaxel. When $S_{0.5}A_{0.5}$ (Silica/Alumina molar ratio = 0.5/0.5) was used, the highest purity (~27%) and yield (~63%) of paclitaxel were obtained from adsorbent treatment and hexane precipitation. Removal of impurities was confirmed by TGA analysis of the organic substances that were adsorbed to the adsorbent.

본 연구에서는 분무열분해(spray pyrolysis)에 의해 다양한 혼합비의 다공성 메조기공 실리카-알루미나 흡착제를 제조하여 항암물질 파클리탁셀(paclitaxel)의 정제에 이용하였다. 흡착제 처리와 헥산 침전을 수행한 결과, $S_{0.5}A_{0.5}$ (Si/Al 몰비 = 0.5/0.5)을 사용하였을 때 가장 높은 순도 (~27%)와 수율 (~63%)의 파클리탁셀을 얻을 수 있었다. 이러한 불순물(타르 및 왁스 성분 포함) 제거 효과는 흡착제에 붙은 유기물의 TGA 정량 분석 결과로도 확인할 수 있었다.

Keywords

References

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