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http://dx.doi.org/10.7464/ksct.2013.19.3.342

Effect of Silica-Alumina Adsorbent on the Efficiency of Paclitaxel Purification  

Oh, Hyeon-Jeong (Department of Chemical Engineering, Kongju National University)
Jung, Kyeong Youl (Department of Chemical Engineering, Kongju National University)
Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
Publication Information
Clean Technology / v.19, no.3, 2013 , pp. 342-346 More about this Journal
Abstract
Several types of mesoporous silica-alumina adsorbents with varied $SiO_2/Al_2O_3$ ratios were prepared by spray pyrolysis and were used for the purification of the anticancer agent paclitaxel. When $S_{0.5}A_{0.5}$ (Silica/Alumina molar ratio = 0.5/0.5) was used, the highest purity (~27%) and yield (~63%) of paclitaxel were obtained from adsorbent treatment and hexane precipitation. Removal of impurities was confirmed by TGA analysis of the organic substances that were adsorbed to the adsorbent.
Keywords
Paclitaxel; Silica-alumina; Adsorbent; Purification;
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Times Cited By KSCI : 4  (Citation Analysis)
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