Transactions of the Korean Society of Mechanical Engineers B (대한기계학회논문집B)

The Korean Society of Mechanical Engineers (대한기계학회)
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Characterization of Porcine Tissue Perforation Using High-Power Near-Infrared Laser at 808-nm Wavelength

808 nm 파장의 고출력 근적외선 레이저 조사 시 돼지 조직의 천공 특성 연구

  • Kim, Seongjun (Dept. of Mechanical Engineering, Graduate School, Kookmin Univ.) ;
  • Cho, Jiyong (Dept. of Mechanical Engineering, Graduate School, Kookmin Univ.) ;
  • Choi, Jaesoon (Asan Institute for Life Sciences, Asan Medical Center, Univ. of Ulsan College of Medicine) ;
  • Lee, Don Haeng (Division of Gastroenterology, Dept. of Internal Medicine, Inha Univ. School of Medicine, National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders, Utah-Inha DDS & Advanced Therapeutics Research Center) ;
  • Kim, Jung Kyung (School of Mechanical Systems Engineering & Dept. of Integrative Biomedical Science and Engineering, Graduate School, Kookmin Univ.)
  • 김성준 (국민대학교 대학원 기계공학과) ;
  • 조지용 (국민대학교 대학원 기계공학과) ;
  • 최재순 (울산대학교 의과대학 서울아산병원 아산생명과학연구원) ;
  • 이돈행 (인하대학교 의과대학 소화기내과, 국가지정 소화기질환 의료제품 유효성평가 서비스센터, (재)유타-인하 DDS 및 신의료기술 개발 공동연구소) ;
  • 김중경 (국민대학교 기계시스템공학부 및 대학원 의생명융합학과)
  • Received : 2013.01.28
  • Accepted : 2013.05.30
  • Published : 2013.09.01
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Abstract

A fundamental study on laser-tissue interaction was conducted with the aim of developing a therapeutic medical device that can remove lesions on the intestinal wall by irradiating a high-power 808-nm infrared laser light incorporated in an endoscopic system. The perforation depth was linearly increased in the range of 1~4 mm in proportional to laser output (3~12 W) and irradiation time (5~20 s). We demonstrated that the perforation depth during laser irradiation was varied according to the tissue property of each extracted porcine organ. The measurement of the temperature distribution suggests that the energy is localized in the irradiation spot and transferred to deep tissue, which protects the surrounding tissue from thermal injury. These results can be used to set the driving parameters for a laser incision technique as an alternative to conventional surgical interventions.

소화기 내시경에 장착된 808 nm 파장의 고출력 근적외선 레이저를 장벽에 조사하여 병변을 제거할 수 있는 치료용 의료기기의 개발을 목적으로 레이저-조직 상호작용에 관한 기초 실험을 진행했다. 레이저 출력 3~12 W, 조사 시간 5~20 s 범위에서 각 변수의 증가에 따라 천공 깊이가 1~4 mm 범위에서 선형적으로 증가했다. 돼지에서 적출한 각 장기에 대한 레이저 조사 시 천공 깊이가 조직 특성에 따라 달라짐을 확인했다. 온도 측정 결과로부터 열에너지가 레이저 조사 지점에 집중되고 심부로 전달되어 주변 조직의 열손상은 방지됨을 알 수 있었다. 본 연구 결과는 위, 대장 등의 소화기 조직에서 일정한 절개 깊이를 얻기 위해 필요한 근적외선 레이저의 구동 조건을 결정하는데 활용될 수 있다.

Keywords

References

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