Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
권호 표지

Effects of a Rice-Based Diet on Body Weight and Serum Lipid Levels in Mice

밥 중심 식사가 마우스의 체중 및 혈중 지질 함량에 미치는 영향

  • Choi, Won Hee (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Um, Min Young (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Ahn, Ji Yun (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Jung, Chang Hwa (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Seo, Jung Sook (Dept. of Food & Nutrition, Yeungnam University) ;
  • Ha, Tae-Youl (Division of Metabolism and Functionality Research, Korea Food Research Institute)
  • 최원희 (한국식품연구원 대사기능연구본부) ;
  • 엄민영 (한국식품연구원 대사기능연구본부) ;
  • 안지윤 (한국식품연구원 대사기능연구본부) ;
  • 정창화 (한국식품연구원 대사기능연구본부) ;
  • 서정숙 (영남대학교 식품영양학과) ;
  • 하태열 (한국식품연구원 대사기능연구본부)
  • Received : 2012.11.15
  • Accepted : 2013.02.19
  • Published : 2013.03.07
Download PDF
⟨ Previous Next ⟩

Abstract

This study was designed to evaluate the effect of a rice-based diet on body weight and serum lipid levels. Thirty male C57BL/6 mice were randomly divided into three groups and fed a high-fat diet (HFD), rice-based diet (RD), or bread-based diet (BD) for five weeks. Our results showed that the RD group had a significantly lower final body weight, although there was no significant difference in daily food intake among the groups. There was a reduction in body weight gains, adipose tissues weight, and adipocyte size of epididymal adipose tissue in the RD group (p<0.05). Also, serum triglycerides and total cholesterol in the RD group were significantly decreased compared to the BD group. RD also reduced fasting glucose and insulin levels. These results indicate that the intake of RD attenuates increases in body weight and serum lipid concentrations in mice, suggesting its benefits for the dietary control of obesity and hyperlipidemia.

본 연구는 밥 중심 식사 패턴이 비만에 미치는 영향을 조사하고자 C57BL/6 마우스를 고지방식이 대조군(HFD), 밥 중심 식사 급여군(RD) 및 빵 중심 식사 급여군(BD)으로 분류하여 각 실험 식이를 5주간 공급하여 마우스의 체중 변화, 혈중 지질 함량, 지방조직의 무게 및 혈중 glucose 및 insulin 함량을 비교 측정하였다. 실험 결과, 모든 처리군에서 사료 섭취량의 유의적인 차이를 나타내지 않았으나, RD 급여군에서의 체중 증가량은 BD 급여군에 비하여 유의적으로 낮아졌다(p<0.05). 지방조직 무게 역시 RD 급여군에서 낮은 수치를 보였으며, 특히 부고환지방의 무게 및 지방세포의 크기는 BD 급여군에 비하여 현저하게 감소하였다. RD 급여군에서의 혈중 중성지방 및 총콜레스테롤, 포도당 및 인슐린 농도 역시 BD 급여군에 비하여 유의적으로 낮았다(p<0.05). 이상의 실험 결과를 종합해 볼 때, 밥 중심의 식사는 고지방 식이를 비롯한 빵 중심 식사에 비하여 체내 지방조직의 축적을 억제하고, 혈중 지질농도를 감소시키며, 혈당의 증가를 억제함으로써 비만 및 당뇨병 등의 대사성 질환을 개선하는 데에 있어서 효과적인 것으로 사료된다.

Keywords

References

  1. 하태열, 김혜영 (1994) 쌀의 영양학적 특성에 관한 연구. 한국식품연구원보고서.
  2. Bjorntorp P (1988) The associations between obesity, adipose tissue distribution and disease. Acta Med Scand Suppl 723: 121-134.
  3. Crapo PA, Insel J, Sperling M, Kolterman OG (1981) Comparison of serum glucose, insulin, and glucagon responses to different type of complex carbohydrate in noninsulindependent diabetic patients. Am J Clin Nutr 34: 184-190.
  4. Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB (2001) Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med 161: 1857-1862. https://doi.org/10.1001/archinte.161.15.1857
  5. Garcia-Diaz DF, Campion J, Milaqro FI, Boque N, Moreno-Aliaga MJ, Martinez JA (2010) Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes. J Mol Endocrinol 45: 33-43. https://doi.org/10.1677/JME-09-0160
  6. Kim JH, Lee JE, Jung IK (2012) Dietary pattern classifications and the association with general obesity and abdominal obesity in Korean women. J Acad Nutr Diet 112: 1550-1559. https://doi.org/10.1016/j.jand.2012.06.369
  7. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF (1996) Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 45: 699-701. https://doi.org/10.2337/diab.45.5.699
  8. Lee HS, Kim BH, Jang YA, Kim CI (2001) Korean National Health and Nutrition Examination Survey -The change of dietary intakes and the intakes of fat. Proceedings of 26th Korean Soc Lipid Atherosclerosis Conference: Seoul, Korea 2003. Sep. pp 26-27.
  9. Lim JH, Lee YS, Chang HC, Moon MK, Song Y (2011) Association between dietary patterns and blood lipid profiles in Korean adults with type 2 diabetes. J Korean Med Sci 26: 1201-1208. https://doi.org/10.3346/jkms.2011.26.9.1201
  10. Lin H, Bermudez OI, Tucker KL (2003) Dietary patterns of Hispanic elders are associated with acculturation and obesity. J Nutr 133: 3651-3657.
  11. McNaughton SA, Mishra GD, Stephen AM, Wadsworth ME (2007) Dietary patterns throughout adult life are associated with body mass index, waist circumference, blood pressure, and red cell folate. J Nutr 137: 99-105.
  12. Newby PK, Muller D, Hallfrisch J, Andres R, Tucker KL (2004) Food patterns measured by factor analysis and anthropometric changes in adults. Am J Clin Nutr 80: 504-513.
  13. Newby PK, Muller D, Hallfrisch J, Qiao N, Andres R, Tucker KL (2003) Dietary patterns and changes in body mass index and waist circumference in adults. Am J Clin Nutr 77: 1417-1425.
  14. Peters BS, Wierzbicki AS, Moyle G, Nair D, Brockmeyer N (2012) The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized, placebo-controlled pilot trial. Clin Ther 34: 67-76. https://doi.org/10.1016/j.clinthera.2011.12.001
  15. Rural Development Administration (2006) Food composition tables. 7th ed. Hyoil, Seoul.
  16. Son SM (2001) Rice based meal for prevention of obesity and chronic disease. Korean J Community Nutr 6: 862-867.
  17. Thornton SJ, Wong IT, Neumann R, Kozlowski P, Wasan KM (2011) Dietary supplementation with phytosterol and ascorbic acid reduces body mass accumulation and alters food transit time in a diet-induced obesity mouse model. Lipids Health Dis 10: 107-120. https://doi.org/10.1186/1476-511X-10-107
  18. Williams DE, Prevost AT, Whichelow MJ, Cox BD, Day NE, Wareham NJ (2000) A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome. Br J Nutr 83: 257-266. https://doi.org/10.1017/S0007114500000337
  19. http://knhanes.cdc.go.kr. Accessed December 9 2012.