한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology)

  • 제26권1호
  • /
  • Pages.35-49
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  • 2013
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  • 1738-6640(pISSN)
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  • 2234-4020(eISSN)
대한한방안이비인후피부과학회 (The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology)
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알레르기 비염 동물 모델에서 유산균 발효 신이(辛夷)의 효과

The Effects of Probiotics-Fermented Magnolia Denudata in Ovalbumin Induced Allergic Rhinitis Animal Model

  • 송민경 (동국대학교 대학원 한의학과 안이비인후피부과교실) ;
  • 홍승욱 (동국대학교 대학원 한의학과 안이비인후피부과교실)
  • Song, Min-Kyung (Dept. of Korean Medical Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dongguk University) ;
  • Hong, Seung-Ug (Dept. of Korean Medical Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dongguk University)
  • 투고 : 2013.01.14
  • 심사 : 2013.02.10
  • 발행 : 2013.02.25
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초록

Objectives : We aimed to determine therapeutic effects of probiotics-fermented Magnolia denudata(MD) in the allergic rhinitis model mice. Methods : Polyphenol production, DPPH radical scavenging activity and NO inhibition of fermented MD by different bacterial strains were evaluated to select the one that is most suitable for fermentation. Thirty C57BL/6 mice were divided randomly into 5 groups as follows: normal group, ovalbumin(OVA)-treated plus water fed(CON group), OVA-treated plus unfermented MD fed(UMD group), OVA-treated plus fermented autoclaved MD fed(A-FMD group) and OVA-treated plus fermented unautoclaved MD fed(FMD group). After 9 weeks, we observed changes in the blood cell count, OVA-specific IgE level, nasal rubbing, nasal mucosal tissue and body weight. Results : Extract of MD fermented by Bifidobacterium breve(BB) for 48 hours showed the highest anti-oxidant activity and anti-inflammatory activity out of all the other bacterial strains. The number of eosinophil count in A-FMD, FMD group and platelet count in FMD group showed statistically significant decrease(p<0.05). OVA-specific IgE level decreased in all 3 experimental groups, significantly in UMD and A-FMD group. Nasal symptoms were attenuated in all 3 experimental groups, statistically significant in A-FMD and FMD group (p<0.05). Histologically, infiltration of eosinophils into the nasal mucosa decreased in all 3 experimental groups, especially marked decrease in FMD group. Conclusions : According to the above results, it is considered that probiotics-fermented Magnolia denudata has inhibitory effects on the allergic rhinitis animal models.

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참고문헌

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피인용 문헌

  1. Oral administration of the Herbal Medicines in animal models for treatment of Allergic Rhinitis: a Review of Animal Study Reports Published in Korea vol.29, pp.1, 2016, https://doi.org/10.6114/jkood.2016.29.1.131
  2. 난알부민으로 유발된 생쥐의 알레르기 비염에 연교, 유근피, 좌귀음이 미치는 영향 vol.31, pp.2, 2013, https://doi.org/10.7778/jpkm.2017.31.2.034