International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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Development of a Porous Scaffold-Manufacturing Method by Blending Silk Fibroin and Agarose Polymer Solutions

  • Park, Seung-Won (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Association) ;
  • Kweon, Hae-Yong (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Association) ;
  • Goo, Tae-Won (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Association) ;
  • Kim, Seong-Ryul (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Association) ;
  • Jo, You-Young (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Association) ;
  • Choi, Gwang-Ho (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Association)
  • Received : 2012.05.15
  • Accepted : 2012.09.04
  • Published : 2012.09.30
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Abstract

Low-melting-temperature agarose gel solution, as a novel porogen was combined with a silk fibroin solution to generate interconnected porous networks. The porosity of the resultant silk fibroin-agarose scaffolds was greater than that of the scaffolds generated with agarose and deionized water. The porosities of silk fibroin scaffolds containing agarose gel at 0.5%, 1.0%, 1.5%, 2.0% [w/v] were 110.9%, 111.7%, 120.9%, and 123.0%, respectively. Lastly, the internal space generated in scaffolds after dissolution of the agarose gel provides a good environment for cell growth and movement within the scaffold.

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References

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